Recombinant Saccharomyces cerevisiae Ribonucleoside-diphosphate reductase large chain 1 (RNR1), partial

中文名稱：

釀酒酵母RNR1重組蛋白
貨號：

CSB-YP321975SVG
規格：
來源：

Yeast
其他：

中文名稱：

釀酒酵母RNR1重組蛋白
貨號：

CSB-EP321975SVG
規格：
來源：

E.coli
其他：

中文名稱：

釀酒酵母RNR1重組蛋白
貨號：

CSB-EP321975SVG-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

釀酒酵母RNR1重組蛋白
貨號：

CSB-BP321975SVG
規格：
來源：

Baculovirus
其他：

中文名稱：

釀酒酵母RNR1重組蛋白
貨號：

CSB-MP321975SVG
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RNR1
Uniprot No.：

P21524
別名：

RNR1; CRT7; RIR1; SDS12; YER070W; Ribonucleoside-diphosphate reductase large chain 1; EC 1.17.4.1; Ribonucleotide reductase R1 subunit 1; Ribonucleotide reductase large subunit 1
種屬：

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
基因功能參考文獻：
1. there is a directed orientation of the RNR beta and beta' C-terminal tails relative to alpha within the holoenzyme consistent with a docking model of the two subunits and argue against RT across the beta beta' interface PMID: 23532842
2. The data reveaedl that the arginine 293 and glutamine 288 residues of ribonucleotide reductase 1 are crucial in facilitating ADP and CDP substrate selection. PMID: 22465672
3. defects in autophagy result in an increase in soluble Rnr1 protein levels and a DNA damage phenotype. PMID: 21343333
4. Data show that Rnr1 transcription requires protein bound to a particular site and either five different sites or one additional sites. PMID: 21103376
5. The structures of the apo-, AMPPNP only-, AMPPNP-CDP-, AMPPNP-UDP-, dGTP-ADP- and TTP-GDP-bound complexes give insight into substrate and effector binding and specificity cross-talk. PMID: 16537479
6. x-ray structures upon binding to gemcitabine diphosphate PMID: 16537480
顯示更多

收起更多
亞細胞定位：

Cytoplasm.
蛋白家族：

Ribonucleoside diphosphate reductase large chain family
數據庫鏈接：

KEGG: sce:YER070W

STRING: 4932.YER070W