Recombinant Mouse Protein HIRA (Hira), partial

中文名稱：

小鼠Hira重組蛋白
貨號：

CSB-YP717222MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Hira重組蛋白
貨號：

CSB-EP717222MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Hira重組蛋白
貨號：

CSB-EP717222MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Hira重組蛋白
貨號：

CSB-BP717222MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Hira重組蛋白
貨號：

CSB-MP717222MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Hira
Uniprot No.：

Q61666
別名：

Hira; Tuple1Protein HIRA; TUP1-like enhancer of split protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for the periodic repression of histone gene transcription during the cell cycle. Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
基因功能參考文獻：
1. These data suggest that elimination of HIRA produces a hypertrophic response in skeletal muscle and leaves myofibers susceptible to stress-induced degeneration. PMID: 28600325
2. transcriptional regulation by HIRA is crucial for cardiomyocyte homeostasis. PMID: 26935106
3. Data show that Hira is important to mediates Histone H3/H4 replacement during mouse oogenesis which is required for normal 5mC deposition in oocytes. Its loss results in chromatin abnormalities and extensive oocyte loss. PMID: 26549683
4. Hira-mediated H3.3 incorporation is essential for parental genome reprogramming and reveal an unexpected role for rRNA transcription in the mouse zygote PMID: 25087892
5. WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition. PMID: 23921552
6. HIRA is an essential factor for muscle development by establishing MyoD activation in myotubes. PMID: 21173268
7. Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality PMID: 11884616
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亞細胞定位：

Nucleus. Nucleus, PML body.
蛋白家族：

WD repeat HIR1 family
組織特異性：

Expressed in cerebrum, cerebellum, heart, kidney, liver, lung and spleen.
數據庫鏈接：

KEGG: mmu:15260

STRING: 10090.ENSMUSP00000004222

UniGene: Mm.15694