Recombinant Mouse Nuclear receptor corepressor 2 (Ncor2), partial

中文名稱：

小鼠Ncor2重組蛋白
貨號：

CSB-YP893883MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Ncor2重組蛋白
貨號：

CSB-EP893883MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Ncor2重組蛋白
貨號：

CSB-EP893883MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ncor2重組蛋白
貨號：

CSB-BP893883MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ncor2重組蛋白
貨號：

CSB-MP893883MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ncor2
Uniprot No.：

Q9WU42
別名：

Ncor2; Smrt; Nuclear receptor corepressor 2; N-CoR2; Silencing mediator of retinoic acid and thyroid hormone receptor; SMRT; SMRTe; T3 receptor-associating factor; TRAC; Thyroid-; retinoic-acid-receptor-associated corepressor
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation.
基因功能參考文獻：
1. Both the acetylation and SUMOylation status of the PXR protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 in a complex with SMRT. PMID: 26883953
2. These studies support a model in which NCOR1/2 mediates direct Retinoic acid-dependent repression of Fgf8 in caudal progenitors in order to control somitogenesis. PMID: 27506116
3. demonstrate that the binding of HDAC3 to IR nGREs in vivo is mediated through interaction with SMRT/NCoR1 PMID: 26712002
4. GR SUMOylation site is mandatory for the formation of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT/NCoR1-HDAC3 repressing complex, which is indispensable for NF-kappaB/AP1-mediated GC-induced tethered indirect transrepression in vitro PMID: 26712006
5. changes in dietary components can consistently, if moderately, modulate the total transcript levels and the mRNA splicing of NCoR and SMRT in both cultured cells and intact mice. PMID: 26166430
6. SMRT regulates glucocorticoid action in adipocytes. PMID: 25766503
7. While silencing mediator of retinoid and thyroid hormone receptor played little role in TH-regulated pathways, when disrupted in combination with nuclear receptor corepressor, it greatly accentuated the synthesis and storage of hepatic lipid PMID: 25421714
8. HDAC3 enzyme activity is undetectable in mice bearing point mutations in the deacetylase-activating domain of both NCOR1 and SMRT. PMID: 23292142
9. These results reveal that Bcl6-SMRT/NCoR complexes constrain immune responses and contribute to the prevention of atherosclerosis. PMID: 22465074
10. SMRT is an adipogenic gatekeeper as it directly fine-tunes transcription of pro- and antiadipogenic genes. PMID: 22521691
11. miR-184 downregulated nuclear receptor corepressor 2 (Ncor2) by targeting its 3' untranslated region through inhibiting NCOR2 protein translation PMID: 22017809
12. Data show that knock-in mutations of the nuclear co-repressor SMRT in C57BL/6 mice produces a previously unidentified respiratory distress syndrome caused by prematurity of the type I pneumocyte. PMID: 22001906
13. essential role of nuclear receptor corepressors in maintaining metabolic homeostasis and describe an essential role for SMRT in regulating the progression, severity, and therapeutic outcome of metabolic diseases PMID: 21300871
14. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. PMID: 21109196
15. SMRT regulates leptin expression and limits the ability of fat mass to expand with increased caloric intake, but SMRT also negatively regulates adipocyte insulin sensitivity PMID: 20371609
16. TR surfaces and conformations required to bind nuclear receptor corepressor PMID: 11818500
17. Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation PMID: 11903058
18. The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. PMID: 11997503
19. the loss of the molecular events of AML1-ETO C-terminal NCoR/SMRT-interacting domain transforms AML1-ETO into a potent leukemogenic protein. PMID: 15569932
20. differential mRNA splicing of SMRT serves to customize corepressor function in different cells, allowing the transcriptional properties of nuclear receptors to be adapted to different contexts PMID: 15632172
21. SMRT primary transcript encoding interaction domains is subject to alternative splicing that varies the inclusion of the third CoRNR box. The profile in mice includes an abundant, novel SMRT isoform that possesses just one CoRNR box. PMID: 16026760
22. SMRT is recruited to PPARgamma via its C-terminal interacting domain. PMID: 16989944
23. Data indicate that SMRT, in conjunction with gene-specific and cell-dependent factors, is required for positively regulating agonist-dependent ERalpha transcriptional activity. PMID: 17591692
24. a critical role for SMRT in forebrain development and in maintenance of the neural stem cell state PMID: 17928865
25. the differential deployment of SMRT isoforms observed in vivo could significantly expand the regulatory capacity of nuclear receptor signalling. PMID: 18752469
26. apoptotic cells induce PPARgamma sumoylation to attenuate the removal of NCoR, thereby blocking transactivation of NF-kappaB. PMID: 18832723
27. These results demonstrate that SMRT receptor interaction domain dependent repression is a key determinant of the adipogenic set point as well as an integrator of glucose metabolism and whole-body metabolic homeostasis. PMID: 19066220
28. Both Nurr1 and Pitx3 interact with the co-repressor PSF and occupy the promoters of Nurr1 target genes in concert. PMID: 19144721
29. the binding of NCoR and SMRT to NCoR/SMRT-dependent promoters is mutually dependent, establishing a requirement for both proteins for LXR transrepression and enabling inflammatory pathways that selectively target NCoR or SMRT PMID: 19299558
30. COUP-TFII/SMRT complex is a component of the linear pathway that directly links Wnt/beta-catenin signaling to repression of PPARgamma gene expression and the inhibition of adipogenesis. PMID: 19307559
31. Findings reveal mechanisms for integration of TLR, calcium, and nuclear receptor signaling pathways. PMID: 19595715
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亞細胞定位：

Nucleus.
蛋白家族：

N-CoR nuclear receptor corepressors family
組織特異性：

Ubiquitous. Also widely expressed in early embryos.
數據庫鏈接：

KEGG: mmu:20602

STRING: 10090.ENSMUSP00000083250

UniGene: Mm.278646