Recombinant Mouse Condensin complex subunit 1 (Ncapd2), partial

中文名稱：

小鼠Ncapd2重組蛋白
貨號：

CSB-YP815660MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Ncapd2重組蛋白
貨號：

CSB-EP815660MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Ncapd2重組蛋白
貨號：

CSB-EP815660MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ncapd2重組蛋白
貨號：

CSB-BP815660MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ncapd2重組蛋白
貨號：

CSB-MP815660MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ncapd2
Uniprot No.：

Q8K2Z4
別名：

Ncapd2; Capd2; Cnap1; Kiaa0159Condensin complex subunit 1; Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; mCAP-D2; Non-SMC condensin I complex subunit D2; XCAP-D2 homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
基因功能參考文獻：
1. Condensins I and II have overlapping and non-overlapping functions in Neural stem cells. PMID: 25474630
2. Knock-down of a condensin subunit protein or YY1 reduced rearrangement of Igkappa Vkappa genes suggesting a direct role for YY1-condensin complexes in Igkappa locus structure and rearrangement. PMID: 23531880
3. Data show that that DNA repear process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I. PMID: 21858164
4. The characterization of two novel E2F target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1) and maternal embryonic leucine zipper kinase (Melk) is reported. PMID: 16144839
亞細胞定位：

Nucleus. Cytoplasm. Chromosome.
蛋白家族：

CND1 (condensin subunit 1) family
數據庫鏈接：

KEGG: mmu:68298

STRING: 10090.ENSMUSP00000042260

UniGene: Mm.257590