Recombinant Mouse ATP synthase-coupling factor 6, mitochondrial (Atp5j)

中文名稱：

Recombinant Mouse ATP synthase-coupling factor 6, mitochondrial(Atp5j)
貨號(hào)：

CSB-YP002369MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse ATP synthase-coupling factor 6, mitochondrial(Atp5j)
貨號(hào)：

CSB-EP002369MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse ATP synthase-coupling factor 6, mitochondrial(Atp5j)
貨號(hào)：

CSB-EP002369MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse ATP synthase-coupling factor 6, mitochondrial(Atp5j)
貨號(hào)：

CSB-BP002369MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse ATP synthase-coupling factor 6, mitochondrial(Atp5j)
貨號(hào)：

CSB-MP002369MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Atp5j
Uniprot No.：

P97450
別名：

Atp5pf; Atp5jATP synthase-coupling factor 6; mitochondrial; ATPase subunit F6; ATP synthase peripheral stalk subunit F6
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

33-108
氨基酸序列

NKELDPVQ KLFVDKIREY KSKRQASGGP VDIGPEYQQD LDRELYKLKQ MYGKGEMDTF PTFKFDDPKF EVIDKPQS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
基因功能參考文獻(xiàn)：
1. Coupling factor 6 overexpression induced salt-sensitive hypertension, complicated by systolic cardiac dysfunction, but its onset was delayed in females. Estrogen has an important role in the regulation of coupling factor 6-mediated pathophysiology. PMID: 22258022
2. Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by downregulating Akt signaling, thereby cancelling its benefit for cardiac function in mice. PMID: 22306848
3. CF6 plays a crucial role in the development of insulin resistance and hypertension PMID: 22038518
4. coupling factor 6 induces the development of systolic dysfunction and upregulation of nicotinamide adenine dinucleotide phosphate oxidase in the heart under the high-salt diet PMID: 20811295
5. identification of functional elements in bi-directional promoter PMID: 16309857
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亞細(xì)胞定位：

Mitochondrion. Mitochondrion inner membrane.
蛋白家族：

Eukaryotic ATPase subunit F6 family
數(shù)據(jù)庫鏈接：

KEGG: mmu:11957

STRING: 10090.ENSMUSP00000023608

UniGene: Mm.353