Recombinant Mouse AT-hook-containing transcription factor (Akna), partial

中文名稱：

Recombinant Mouse AT-hook-containing transcription factor(Akna) ,partial
貨號：

CSB-YP802235MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse AT-hook-containing transcription factor(Akna) ,partial
貨號：

CSB-EP802235MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse AT-hook-containing transcription factor(Akna) ,partial
貨號：

CSB-EP802235MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse AT-hook-containing transcription factor(Akna) ,partial
貨號：

CSB-BP802235MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse AT-hook-containing transcription factor(Akna) ,partial
貨號：

CSB-MP802235MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Akna
Uniprot No.：

Q80VW7
別名：

Akna; Kiaa1968; Microtubule organization protein AKNA; AT-hook-containing transcription factor
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization. Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis. Also regulates the epithelial-to-mesenchymal transition in other epithelial cells. Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot. In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters. It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions.
基因功能參考文獻：
1. targeted deletions of mouse AKNA, a hypothetical AT-hook-like transcription factor, sensitize mice to pathogen-induced inflammation and cause sudden neonatal death PMID: 21606955
亞細胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
組織特異性：

Expressed in neural stem cells isolated at the peak of subventricular zone (SVZ): localizes at the subdistal appendages of the mother centriole in specific subtypes of neural stem cells and in almost all basal progenitors.
數據庫鏈接：

KEGG: mmu:100182

STRING: 10090.ENSMUSP00000041614

UniGene: Mm.387725