Recombinant Human Kinesin-like protein KIF13A (KIF13A), partial

中文名稱：

人KIF13A重組蛋白
貨號：

CSB-YP880944HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人KIF13A重組蛋白
貨號：

CSB-EP880944HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人KIF13A重組蛋白
貨號：

CSB-EP880944HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人KIF13A重組蛋白
貨號：

CSB-BP880944HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人KIF13A重組蛋白
貨號：

CSB-MP880944HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

KIF13A
Uniprot No.：

Q9H1H9
別名：

bA500C11.2 ; FLJ27232; Homolog of mouse KIF13A mannose 6 phosphate receptor transporter; KI13A_HUMAN; KIF 13A; Kif13a; Kinesin family member 13A; Kinesin like protein KIF13A; Kinesin like protein RBKIN ; Kinesin-like protein KIF13A; Kinesin-like protein RBKIN; RBKIN
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.
基因功能參考文獻：
1. the crystal structure of a catalytically active kinesin-13 monomer (Kif2A) in complex with two bent alphabeta-tubulin heterodimers in a head-to-tail array, providing a view of these interactions, is reported. PMID: 29980677
2. that KIF13A plays an important role in the transport of influenza A viral ribonucleoproteins PMID: 29061883
3. KIF13A interacts and cooperates with RAB11 to generate endosomal tubules. PMID: 24462287
4. kjh kiiou ouiy 8yt 8iy 7i9y PMID: 24859087
5. the kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization PMID: 21873978
6. Functionally characterizes the homologous mouse protein. PMID: 11106728
7. PtdIns(3)P production is essential for proper cytokinesis. PtdIns(3)P-binding centrosomal protein FYVE-CENT and TTC19 control cytokinesis through their translocation from the centrosome to the midbody mediated by the kinesin protein KIF13A. PMID: 20208530
8. show that the clathrin adaptor AP-1 and the kinesin motor KIF13A together create peripheral recycling endosomal subdomains in melanocytes required for cargo delivery to maturing melanosomes. PMID: 19841138
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亞細胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane. Note=Recruited to the midbody during cytokinesis.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
組織特異性：

Widely expressed, with highest levels in heart, brain and skeletal muscle.
數據庫鏈接：

HGNC: 14566

OMIM: 605433

KEGG: hsa:63971

STRING: 9606.ENSP00000259711

UniGene: Hs.94499