Recombinant Human Alpha-tectorin (TECTA), partial

中文名稱：

人TECTA重組蛋白
貨號：

CSB-YP023370HU
規格：
來源：

Yeast
其他：

中文名稱：

人TECTA重組蛋白
貨號：

CSB-EP023370HU
規格：
來源：

E.coli
其他：

中文名稱：

人TECTA重組蛋白
貨號：

CSB-EP023370HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TECTA重組蛋白
貨號：

CSB-BP023370HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人TECTA重組蛋白
貨號：

CSB-MP023370HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TECTA
Uniprot No.：

O75443
別名：

TECTA; Alpha-tectorin
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
基因功能參考文獻：
1. TECTA mutations were identified in 6.0% of mid-frequency sensorineural hearing loss cases; these mutations were more frequent in patients with shallow U-shaped audiograms than those with U-shaped audiograms, and in families which have the family histories compatible with autosomal dominant than those with the family histories compatible with sporadic or autosomal recessive. PMID: 28946916
2. Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4), DFNA8/12 (TECTA), DFNA13 (COL11A2), DFNA44 (CCDC50), have been reported to date. [review] PMID: 27142990
3. A novel homozygous variant (c.734G > A) was found in exon 5 of the TECTA gene in one family leading to a nonsense mutation causing autosomal recessive nonsyndromic hearing loss. PMID: 28012541
4. To our knowledge, this is the first reported TECTA mutation leading to the DFNB21 form of hearing impairment among Maghrebian individuals suffering from congenital hearing impairment PMID: 27368438
5. the present report suggest that the association of RWDD3 and TECTA with paclitaxel-induced peripheral neuropathy may have been a false positive signal PMID: 25549536
6. Here we confirm a known genotype-phenotype correlation for the ZP domain and propose a hypothetical genotype-phenotype correlation which relates mutations in vWFD3-D4 to stable high-frequency NSHL in Koreans. PMID: 25413827
7. Whole-exome sequencing identifies a novel genotype-phenotype correlation in the entactin domain of the known deafness gene TECTA. PMID: 24816743
8. Identified the c.211delC mutation in the KCNQ4 gene and the c.2967C>A (p.H989Q) mutation in the TECTA gene to be associated with high-frequency sensorineural hearing loss in a Japanese family. PMID: 24655070
9. A rare novel mutation in TECTA causes autosomal dominant nonsyndromic hearing loss in a Mongolian family. PMID: 25008054
10. Data indicate that sequencing of candidate gene TECTA (alpha-tectorin) revealed a heterozygous c.5945C>A substitution in exon 19, causing amino acid substitution of Ala to Asp at a conservative position 1982. PMID: 23936151
11. this study failed to replicate a GWAS reporting an association between the 2 SNPs rs2296308 in RWDD3 and rs1829 in the intron of TECTA and time to neuropathy in ovarian cancer patients treated with paclitaxel PMID: 22877241
12. we have reported the prevalence of TECTA mutations in Japanese autosomal dominant nonsyndromic hearing loss (ADNSHL) patients detected by genetic screening, and confirmed the genotype-phenotype correlations. PMID: 22718023
13. analysis allowed us to identify an aberrant transcript with skipping of exon 16, without affecting the reading frame. One of the dominant TECTA mutations already described, a synonymous substitution in exon 16 PMID: 22995349
14. Here, we identified a missense mutation (p.C1691F) and a splicing mutation (c.6162+3insT), one in each TECTA allele, in the patient with hearing loss. PMID: 22037481
15. mutations in the N-terminal region of alpha-tectorin lead to mid-frequency nonsyndromic hearing loss PMID: 21520338
16. data identify CEACAM16 as an alpha-tectorin-interacting protein that concentrates at the point of attachment of the TM to the stereocilia and, when mutated, results in ADNSHL at the DFNA4 locus PMID: 21368133
17. Mutation analysis of the TECTA gene was performed in 62 Korean patients with hereditary hearing loss. PMID: 20947814
18. The tectorial membrane was shortened in heterozygous Tecta(C1509G/+) mice, reaching only the first row of outer hair cells. PMID: 20142329
19. distinctive phenotype associated with homozygosity for two novel frameshift mutations (649insC and 6037delG) of TECTA cosegregating with hearing loss linked to DFNB21 PMID: 12746400
20. A nucleotide change in exon 13, 4526T>G, was detected leading to a substitution from cysteine to glycine at codon 1509 of the TECTA protein and causing hearing impairment. PMID: 15319541
21. The presently identified mutation affecting the zona pellucida (ZP) domain resulted in a substantially lesser degree of hearing impairment than was previously reported for DFNA8/12 traits with mutations affecting the ZP domain of alpha-tectorin. PMID: 16718611
22. the sensorineural hearing impairment in TECTA mutations may be characterized as a cochlear conductive hearing impairment PMID: 17136632
23. Study described six TECTA mutations in autosomal recessive nonsyndromic hearing loss Iranian families PMID: 17431902
24. Identification of a p.Cys1837Arg autosomal dominant mutation in alpha-tectorin segregating in family members with non-syndromic hearing loss. PMID: 17661817
25. In this study, seventy-five Iranian families segregating autosomal recessive non-syndromic hearing impairment were analyzed. By sequencing all 23 coding exons of TECTA, a frameshift mutation was found. PMID: 18022253
26. Mid-frequency DFNA8/12 hearing loss caused by a synonymous TECTA mutation. PMID: 18575463
27. A single nucleotide mutation in a Dutch family caused nonsyndromic autosomal dominant sensorineural hearing impairmentm PMID: 19005249
28. cysteine substitution in the zona pellucida domain of alpha-tectorin results in autosomal dominant, postlingual, progressive, mid frequency hearing loss in a Spanish family PMID: 11333869
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相關疾病：

Deafness, autosomal dominant, 12 (DFNA12); Deafness, autosomal recessive, 21 (DFNB21)
亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
數據庫鏈接：

HGNC: 11720

OMIM: 601543

KEGG: hsa:7007

STRING: 9606.ENSP00000264037

UniGene: Hs.248162