DCT Antibody

說明書

中文名稱：

DCT兔多克隆抗體
貨號：

CSB-PA282142
規格：

￥1090
圖片：
Western blot analysis of HELA A549 Cell Lysate, antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

P40126
基因名：

DCT
別名：

L dopachrome tautomerase antibody; DCT antibody; Dopachrome delta isomerase antibody; Dopachrome tautomerase antibody; Dopachrome tautomerase dopachrome delta isomerase; tyrosine related protein 2 antibody; DT antibody; EC 5.3.3.12 antibody; L dopachrome Delta isomerase antibody; L-dopachrome Delta-isomerase antibody; L-dopachrome tautomerase antibody; TRP 2 antibody; TRP-2 antibody; TRP2 antibody; Tyrosinase related protein 2 antibody; Tyrosinase-related protein 2 antibody; TYRP2 antibody; TYRP2_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthetic peptide from Human protein at AA range: 1268-1341
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
純化方式：

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB,ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000-1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).
基因功能參考文獻：
1. High DCT expression is associated with progressive multiple sclerosis. PMID: 28923927
2. High DCT expression is associated with HPV16 Infection. PMID: 28095444
3. Data indicate that the caveolin-1 (CAV1) control on dopachrome tautomerase (DCT) gene expression, DCT post-translational processing, and subcellular distribution is cell phenotype-dependent. PMID: 27053106
4. The effect of DCT on UVR DNA damage responses and survival pathways in melanocytes was examined by knockdown experiments using melanoma cells, neonatal melanoblasts in monoculture and in co-culture with keratinocytes. PMID: 25346513
5. Report dopachrome tautomerase expression in mealanocytic tumors. PMID: 24709887
6. The results suggested that the miRNAs may be involved in MITF regulation of TYR, TYRP1 and TYRP2, which provides a new clue for understanding the role of miRNAs in melanocyte dysfunctional disease. PMID: 22898827
7. Data suggest that macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT) act cooperatively to inhibit steady-state phosphorylation and activation of AMPK in LKB1 wild type and LKB1 mutant non-small cell lung carcinomas cells. PMID: 22988252
8. human TRP2 counteracts apoptotic cell death induction, possibly by means of its L-dopachrome tautomerase activity, and negatively affects the p53 pathway PMID: 20520707
9. Trp2 SNP2 allele is a risk factor for the development and severity of degenerative disc disease in a Chinese Han population. PMID: 20356546
10. Data suggest that OTX2 may regulate retinal pigment epithelium (RPE)-specific target genes, such as DOPAchrome tautomerase (DCT), thereby maintaining the homeostasis of RPE. PMID: 12559959
11. Because TRP-2(181-190) overlaps with the known HLA-A*0201-presented epitope TRP-2(180-188), an 11mer peptide encompassing both epitopes might be of specific value for vaccination of a broad population of melanoma patients. PMID: 15856458
12. Transgenic Dct regulates neural progenitor cell proliferation in a mouse model. PMID: 16857183
13. No genetic susceptibility or increased risk attributed to the tyrosinase gene family in Vogt-Koyanagi-Harada disease in Japanese. PMID: 17200659
14. Anemonin, an active compound of C. crassifolia, inhibits melanin synthesis by inhibiting the transcription of the genes encoding TYR, TRP1, and TRP2. PMID: 17766092
15. we studied a possible role of dopachrome tautomerase in the oxidative stress response in the amelanotic WM35 melanoma cell line. PMID: 18206123
16. We observe strong evidence for positive selection for DCT in Asians PMID: 18312627
17. Tyrosinase-, gp100-, or TRP-2-specific CD8(+) T cells could not be identified in the peripheral blood of individuals with vitiligo [TRP-2]. PMID: 18337837
18. TRP-2 acts on quinone metabolites other than DOPAchrome, e.g., in the catecholamine pathway, and limits their deleterious effects. PMID: 18674612
19. tyrosinase-related protein 2 (TRP-2) transcript is not detected in the peripheral blood mononuclear cells (PBMC) of vitiligo patients PMID: 19284502
20. Expression profiling demonstrated that the DCT-expressing cell population expressed adrenergic and muscarinic receptors and displayed transcriptional profiles distinct from dermal melanocytes PMID: 19855129
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亞細胞定位：

Melanosome membrane; Single-pass type I membrane protein. Melanosome.
蛋白家族：

Tyrosinase family
數據庫鏈接：

HGNC: 2709

OMIM: 191275

KEGG: hsa:1638

UniGene: Hs.301865

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