UBE2F
UBE2F，全稱為泛素結合酶E2 F (putative)，是一種參與泛素化過程的酶。泛素化是指泛素分子與靶蛋白結合的過程，這一過程通常會導致靶蛋白被蛋白酶體降解，從而調節蛋白質的穩定性。UBE2F蛋白的異常表達或活性變化與多種癌癥的發生發展密切相關，如肺癌、乳腺癌等。此外，UBE2F蛋白在神經退行性疾病中也可能參與異常蛋白聚集的清除障礙。
針對UBE2F蛋白的藥物研發主要集中在抑制其泛素化活性或阻斷其與底物蛋白的結合。例如，MLN4924是一種NAE抑制劑，可以通過共價結合NEDD8，阻斷NAE催化活性，從而抑制所有Cullin蛋白的擬素化修飾，進而影響腫瘤細胞的增殖和凋亡。此外，也有研究者探索通過激活特定CRL的活性或促進特定CRL與特定底物蛋白的結合，來誘導促癌蛋白的降解，從而實現抗腫瘤治療。
熱銷產品
Recombinant Human NEDD8-conjugating enzyme UBE2F (UBE2F) (CSB-EP850248HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
UBE2F Antibody (CSB-PA850248ESR1HU)
驗證數據
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA850248ESR1HU at dilution of 1:100
UBE2F Antibodies
UBE2F for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA025452GA01HU | UBE2F Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA850248ESR1HU | UBE2F Antibody | Human | ELISA, IHC |
UBE2F Proteins
UBE2F Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP633524BO CSB-EP633524BO CSB-BP633524BO CSB-MP633524BO CSB-EP633524BO-B |
Recombinant Bovine NEDD8-conjugating enzyme UBE2F (UBE2F) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP705800XBF CSB-EP705800XBF CSB-BP705800XBF CSB-MP705800XBF CSB-EP705800XBF-B |
Recombinant Xenopus tropicalis NEDD8-conjugating enzyme UBE2F (ube2f) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP726525CH CSB-EP726525CH CSB-BP726525CH CSB-MP726525CH CSB-EP726525CH-B |
Recombinant Chicken NEDD8-conjugating enzyme UBE2F (UBE2F) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP729235RA CSB-EP729235RA CSB-BP729235RA CSB-MP729235RA CSB-EP729235RA-B |
Recombinant Rat NEDD8-conjugating enzyme UBE2F (Ube2f) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP746935XBE CSB-EP746935XBE CSB-BP746935XBE CSB-MP746935XBE CSB-EP746935XBE-B |
Recombinant Xenopus laevis NEDD8-conjugating enzyme UBE2F (ube2f) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP764689DIL CSB-EP764689DIL CSB-BP764689DIL CSB-MP764689DIL CSB-EP764689DIL-B |
Recombinant Danio rerio NEDD8-conjugating enzyme UBE2F (ube2f) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP850248HU CSB-BP850248HU CSB-MP850248HU CSB-EP850248HU-B |
Recombinant Human NEDD8-conjugating enzyme UBE2F (UBE2F) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP850248HU | Recombinant Human NEDD8-conjugating enzyme UBE2F (UBE2F) | E.coli |
UBE2F Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP883941MO CSB-EP883941MO CSB-BP883941MO CSB-MP883941MO CSB-EP883941MO-B |
Recombinant Mouse NEDD8-conjugating enzyme UBE2F (Ube2f) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
