TP63
TP63，即腫瘤蛋白63，是一種在多種腫瘤中表達(dá)的p53家族成員。它來(lái)源于p53基因的替代剪接，具有多種剪接變體，通過(guò)不同的剪接事件產(chǎn)生。TP63的作用機(jī)制涉及細(xì)胞周期調(diào)控、細(xì)胞凋亡、DNA損傷反應(yīng)和細(xì)胞分化等過(guò)程。它通過(guò)與DNA結(jié)合和激活或抑制特定基因的轉(zhuǎn)錄來(lái)發(fā)揮其生物學(xué)功能。TP63參與的信號(hào)通路包括p53信號(hào)通路、Wnt/β-catenin信號(hào)通路和TGF-β信號(hào)通路等。在生物學(xué)上，TP63對(duì)維持組織再生能力、促進(jìn)細(xì)胞分化和抑制腫瘤發(fā)展具有重要意義。其功能異常可能與多種疾病的發(fā)生發(fā)展相關(guān)，是腫瘤治療和組織再生研究中的一個(gè)重要靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human Tumor protein 63 (TP63) (CSB-EP887971HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TP63 Recombinant Monoclonal Antibody (CSB-RA887971A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: PC3 whole cell lysate
All lanes: TP63 antibody at 2.1μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 66, 63, 52, 56, 45, 58, 47, 68, 57, 77 KDa
Observed band size: 77 KDa
IHC image of CSB-RA887971A0HU diluted at 1:210 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
TP63 Antibodies
TP63 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA024091GA01HU | TP63 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA085904 | TP63 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA172231 | Phospho-TP63 (Ser395) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000705 | Phospho-TP63 (S455) Antibody | Human | WB, IHC, ELISA |
| CSB-PA005081 | TP63 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA070107 | Phospho-TP63 (S395) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA070108 | TP63 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
| CSB-PA158988 | TP63 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA900875 | TP63 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-RA887971A0HU | TP63 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
TP63 Proteins
TP63 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP024091MO CSB-EP024091MO CSB-BP024091MO CSB-MP024091MO CSB-EP024091MO-B |
Recombinant Mouse Tumor protein 63 (Tp63) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TP63 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP884930RA CSB-EP884930RA CSB-BP884930RA CSB-MP884930RA CSB-EP884930RA-B |
Recombinant Rat Tumor protein 63 (Tp63) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TP63 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP887971HU CSB-BP887971HU CSB-MP887971HU CSB-EP887971HU-B |
Recombinant Human Tumor protein 63 (TP63) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP887971HU | Recombinant Human Tumor protein 63 (TP63) | E.coli |
