TNFSF8
CD30配體（CD30L）又名“CD153”或“腫瘤壞死因子配體家族成員8（TNFSF8）”，它是一種Ⅱ型糖蛋白，分子量為40kDa。CD30L蛋白有一個胞外區，構成C端172個氨基酸，胞漿區為N端有40個氮基酸殘基。胞外區與TNF-a、TNF-β和CD40L有明顯的同源性，同其它TNF家族蛋白一樣，CD30L以三聚體形式存在。CD30L是否也像CD40L、TNF-a那樣有可溶性形式存在，目前還不清楚。CD30L除表達在許多髓質上皮細胞外，也表達于外周血的中性粒細胞、嗜酸性粒細胞、靜止B細胞、活化的T細胞。靜止的T細胞不表達CD30L。大量的研究結果表明CD30與CD30L特異性結合后，才能產生活化信號，促發細胞內信息傳遞過程，導致細胞增生、分化、細胞因子的分泌、細胞生長受阻或凋亡。目前，研究人員發現CD30/CD30L軸在自身免疫性疾病、某些病毒感染及腫瘤中發揮重要作用。
Recombinant Human TNFSF8 活性蛋白實驗驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CD30(CSB-MP023983HU1h6) at 5 μg/ml can bind human CD30L, the EC50 is 9.531-12.49 ng/ml.
TNFSF8 Antibodies
TNFSF8 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA951710 | TNFSF8 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA006282 | TNFSF8 Antibody | Human | WB, ELISA |
| CSB-PA009041 | TNFSF8 Antibody | Human,Mouse | WB, IF, ELISA |
TNFSF8 Proteins
TNFSF8 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023996HU1 CSB-EP023996HU1 CSB-BP023996HU1 CSB-EP023996HU1-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF023996HU | Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8) | in vitro E.coli expression system |
| CSB-MP023996HU1 | Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8), partial (Active) | Mammalian cell |
| CSB-MP023996HU1c9 | Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8), partial (Active) | Mammalian cell |
TNFSF8 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023996MO1 CSB-EP023996MO1 CSB-BP023996MO1 CSB-MP023996MO1 CSB-EP023996MO1-B |
Recombinant Mouse Tumor necrosis factor ligand superfamily member 8 (Tnfsf8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023996MO | Recombinant Mouse Tumor necrosis factor ligand superfamily member 8 (Tnfsf8) | in vitro E.coli expression system |
TNFSF8 ELISA Kit
TNFSF8 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04715m | Mouse Soluble Cluster of differentiation 30 ligand,sCD30L ELISA Kit | serum, plasma, tissue homogenates | 0.039 ng/ml |
