TCF3
TCF3，即轉錄因子3，別名E2A免疫球蛋白增強子結合蛋白、B-cell-specific transcription factor 3 (Bcl-3) 等。TCF3是一種基本螺旋-環-螺旋 (bHLH) 結構域的轉錄因子，屬于T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) 家族成員。它在多種細胞類型中都有表達，并且在細胞增殖、分化、遷移和凋亡等過程中發揮重要作用。TCF3的作用機制涉及到與多種蛋白質和DNA序列的相互作用，能夠調控下游基因的表達。TCF3在生物學上的意義非常廣泛，它不僅參與了細胞的正常生理過程，還與多種疾病的發生發展密切相關。TCF3作為Wnt/β-catenin信號通路的主要效應分子，通過與β-catenin相互作用調控靶基因的轉錄。在腫瘤細胞中，TCF3的表達水平和活性與腫瘤的侵襲性、轉移和耐藥性有關，使其成為癌癥治療的潛在靶點。此外，TCF3還在干細胞的維持和分化中發揮作用，影響組織再生和發育。因此，對TCF3的研究不僅有助于我們理解其在正常生理過程中的作用，也為疾病的診斷和治療提供了新的視角。
熱銷產品
驗證數據
Western blot analysis of extracts from 293 cells, using TCF3 antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using TCF3 antibody.
TCF3 Antibodies
TCF3 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA023301GA01HU | TCF3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA123008 | Phospho-TCF3 (Thr355) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA079787 | TCF3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA004248 | TCF3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA050218 | Phospho-TCF3 (T355) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA050219 | TCF3 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA023301HA01HU | TCF3 Antibody | Human | ELISA, IHC |
| CSB-PA023301HB01HU | TCF3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023301HD01HU | TCF3 Antibody, Biotin conjugated | Human | ELISA |
TCF3 Proteins
TCF3 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023301HU CSB-EP023301HU CSB-BP023301HU CSB-MP023301HU CSB-EP023301HU-B |
Recombinant Human Transcription factor E2-alpha (TCF3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF3 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023301RA CSB-EP023301RA CSB-BP023301RA CSB-MP023301RA CSB-EP023301RA-B |
Recombinant Rat Transcription factor E2-alpha (Tcf3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF3 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023301MO CSB-EP023301MO CSB-BP023301MO CSB-MP023301MO CSB-EP023301MO-B |
Recombinant Mouse Transcription factor E2-alpha (Tcf3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF3 Proteins for Mesocricetus auratus (Golden hamster)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023301MRG CSB-EP023301MRG CSB-BP023301MRG CSB-MP023301MRG CSB-EP023301MRG-B |
Recombinant Mesocricetus auratus Transcription factor E2-alpha (TCF3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
