SOST
SOST，即硬化蛋白，別名Sclerostin、VBCH。它是一種由SOST基因編碼的分泌型糖蛋白，屬于Cerberus/Dan家族的骨形態(tài)發(fā)生蛋白(BMP)拮抗劑。SOST在骨骼系統(tǒng)中由骨細(xì)胞產(chǎn)生，具有抗骨形成作用。其作用機(jī)制主要是通過與LRP5/6受體結(jié)合，抑制Wnt信號通路，從而對骨形成產(chǎn)生抑制作用。SOST對維持骨穩(wěn)態(tài)、骨密度維持和骨折愈合等方面至關(guān)重要，其異常表達(dá)與多種骨骼疾病相關(guān)，包括骨質(zhì)疏松癥、骨折愈合障礙以及遺傳性骨疾病如硬化性骨病和van Buchem病等，是治療代謝性骨病和促進(jìn)骨折修復(fù)的潛在治療靶點(diǎn)。
熱銷產(chǎn)品
SOST Recombinant Monoclonal Antibody (CSB-RA858415MA1HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA858415MA1HU diluted at 1：100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA858415MA1HU diluted at 1：100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
Human Sclerostin(SOST) ELISA Kit (CSB-E13146h)
驗(yàn)證數(shù)據(jù)
貨號：CSB-E13146h
規(guī)格：96T/48T
靈敏度：7.8 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
SOST Antibodies
SOST for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA858415ESR1HU | SOST Antibody | Human | ELISA, IHC |
| CSB-PA858415ESR2HU | SOST Antibody | Human | ELISA, WB, IHC |
| CSB-PA020254 | SOST Antibody | Human | WB, ELISA |
| CSB-RA858415MA1HU | SOST Recombinant Monoclonal Antibody | Human | ELISA, IHC |
SOST Proteins
SOST Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP858168MO CSB-EP858168MO CSB-EP858168MO-B |
Recombinant Mouse Sclerostin (Sost) | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP858168MO | Recombinant Mouse Sclerostin (Sost) | Baculovirus |
| CSB-MP858168MO | Recombinant Mouse Sclerostin (Sost) | Mammalian cell |
SOST Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP858374DSU CSB-EP858374DSU CSB-BP858374DSU CSB-MP858374DSU CSB-EP858374DSU-B |
Recombinant Chlorocebus aethiops Sclerostin (SOST) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SOST Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP858415HU CSB-EP858415HU CSB-BP858415HU CSB-MP858415HU CSB-EP858415HU-B |
Recombinant Human Sclerostin (SOST) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP858415HU-B | Recombinant Human Sclerostin (SOST), Biotinylated | Mammalian cell |
SOST Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP859165RA CSB-EP859165RA-B |
Recombinant Rat Sclerostin (Sost) | Yeast In Vivo Biotinylation in E.coli |
| CSB-EP859165RA | Recombinant Rat Sclerostin (Sost) | E.coli |
| CSB-BP859165RA | Recombinant Rat Sclerostin (Sost) | Baculovirus |
| CSB-MP859165RA | Recombinant Rat Sclerostin (Sost) | Mammalian cell |
SOST Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP860205BO CSB-EP860205BO CSB-BP860205BO CSB-MP860205BO CSB-EP860205BO-B |
Recombinant Bovine Sclerostin (SOST) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SOST ELISA Kit
SOST ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13146h | Human Sclerostin(SOST) ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
SOST ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL022415RA | Rat Sclerostin(SOST) ELISA kit | serum, plasma, tissue homogenates | 4.68 pg/mL |
