S100A4

S100A4蛋白全稱為鈣結(jié)合蛋白S100A4，也被稱為轉(zhuǎn)移素或p9Ka，是一種多功能小分子蛋白。它通過與細胞內(nèi)不同靶點結(jié)合，影響細胞骨架動態(tài)變化，促進細胞運動及侵襲能力，尤其在腫瘤轉(zhuǎn)移過程中扮演關(guān)鍵角色。S100A4常與乳腺癌、結(jié)直腸癌等多種惡性腫瘤的侵襲性生長和遠端擴散密切相關(guān)，其高表達常提示患者預(yù)后不良。此外，在肺纖維化、類風(fēng)濕性關(guān)節(jié)炎等慢性疾病中，S100A4也被發(fā)現(xiàn)參與組織異常重塑和炎癥反應(yīng)調(diào)控。
近年來研究發(fā)現(xiàn)，抑制S100A4功能可有效減緩腫瘤轉(zhuǎn)移進程。多個研究團隊正在開發(fā)針對該蛋白的小分子抑制劑和單克隆抗體，其中部分化合物已在動物模型中顯示出阻斷癌細胞遷移的效果。某些已上市藥物如二甲雙胍被發(fā)現(xiàn)具有間接調(diào)控S100A4表達的作用，這為老藥新用提供了潛在方向。學(xué)術(shù)界與制藥企業(yè)正通過結(jié)構(gòu)生物學(xué)手段解析其三維構(gòu)象，以期設(shè)計出更精準(zhǔn)的靶向治療藥物。

熱銷產(chǎn)品

Recombinant Human Protein S100-A4 (S100A4) (CSB-EP020632HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

S100A4 Antibody (CSB-PA020632HA01HU)

驗證數(shù)據(jù)

Western blot
All lanes: S100A4 antibody at 2µg/ml + A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 12 kDa
Observed band size: 12 kDa

IHC image of CSB-PA020632HA01HU diluted at 1:600 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA020632HA01HU diluted at 1:600 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

S100A4 Antibody

S100A4 Protein

S100A4 ELISA Kit

S100A4 Antibodies

S100A4 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA020632HD01HU	S100A4 Antibody, Biotin conjugated	Human	ELISA
CSB-PA020632HC01HU	S100A4 Antibody, FITC conjugated	Human
CSB-PA020632HB01HU	S100A4 Antibody, HRP conjugated	Human	ELISA
CSB-PA020632HA01HU	S100A4 Antibody	Human	ELISA, WB, IHC
CSB-PA286071	S100A4 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA443727	S100A4 Antibody	Human	ELISA,IHC
CSB-PA929601	S100A4 Antibody	Human	ELISA,WB,IHC

S100A4 Proteins

S100A4 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP020632HU CSB-BP020632HU CSB-MP020632HU CSB-EP020632HU-B	Recombinant Human Protein S100-A4 (S100A4)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP020632HU	Recombinant Human Protein S100-A4 (S100A4)	E.coli

S100A4 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP020632BO CSB-EP020632BO CSB-BP020632BO CSB-MP020632BO CSB-EP020632BO-B	Recombinant Bovine Protein S100-A4 (S100A4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

S100A4 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP020632RA CSB-BP020632RA CSB-MP020632RA CSB-EP020632RA-B	Recombinant Rat Protein S100-A4 (S100a4)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP020632RA	Recombinant Rat Protein S100-A4 (S100a4)	E.coli

S100A4 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP020632MO CSB-EP020632MO CSB-BP020632MO CSB-MP020632MO CSB-EP020632MO-B	Recombinant Mouse Protein S100-A4 (S100a4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

S100A4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP883309DO CSB-EP883309DO CSB-BP883309DO CSB-MP883309DO CSB-EP883309DO-B	Recombinant Dog Protein S100-A4 (S100A4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli