PDGFRA
PDGFRA，即血小板衍生生長因子受體α，別名PDGFR-α、CD140A等。它是一種I型跨膜受體酪氨酸激酶，由人體細(xì)胞自身的基因編碼。PDGFRA的作用機制主要是通過與其配體血小板衍生生長因子AA（PDGF-AA）、PDGF-AB、PDGF-CC等結(jié)合，引發(fā)受體二聚化和自身磷酸化，進(jìn)而激活下游的信號傳導(dǎo)途徑。PDGFRA的激活可以促進(jìn)多種細(xì)胞類型的增殖、遷移和存活，包括成纖維細(xì)胞、周細(xì)胞和血管平滑肌細(xì)胞等。PDGFRA在生物學(xué)上的意義非常廣泛，它在胚胎發(fā)育、組織修復(fù)、腫瘤發(fā)生發(fā)展等過程中發(fā)揮關(guān)鍵作用。PDGFRA信號的異常激活與多種腫瘤的發(fā)生發(fā)展密切相關(guān)，如胃腸道間質(zhì)瘤、神經(jīng)膠質(zhì)瘤等。此外，PDGFRA還參與調(diào)控腫瘤微環(huán)境中的血管生成和免疫細(xì)胞的浸潤，影響腫瘤的免疫逃逸和藥物耐受。因此，PDGFRA是腫瘤治療中的一個重要靶點，針對PDGFRA的小分子抑制劑和單克隆抗體等藥物已在臨床治療中得到應(yīng)用。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human PDGFRA at 2 μg/ml can bind Anti-PDGFRA recombinant antibody (CSB-RA017712MA1HU). The EC50 is 0.6497-0.8371 ng/mL.
The purity of PDGFRA was greater than 95% as determined by SEC-HPLC
PDGFRA Antibody (CSB-PA017712LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: HEK293 whole cell lysate, Mouse liver tissue
All lanes: PDGFRA antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 123, 25, 83 kDa
Observed band size: 123 kDa
Immunofluorescent analysis of U251 cells using CSB-PA017712LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
PDGFRA Antibodies
PDGFRA for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA123585 | Phospho-PDGFRA (Tyr849) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA003724 | PDGFRA Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA005257 | PDGFRA Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA020304 | Phospho-PDGFRA (Y849) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020305 | Phospho-PDGFRA (Y762) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA020306 | Phospho-PDGFRA (Y754) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020307 | PDGFRA Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA020308 | PDGFRA Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA030000 | PDGFRA Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA030001 | PDGFRA Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA017712LA01HU | PDGFRA Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA017712LB01HU | PDGFRA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA017712LC01HU | PDGFRA Antibody, FITC conjugated | Human | |
| CSB-PA017712LD01HU | PDGFRA Antibody, Biotin conjugated | Human | ELISA |
PDGFRA Proteins
PDGFRA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017712HU CSB-EP017712HU CSB-BP017712HU CSB-MP017712HU CSB-EP017712HU-B |
Recombinant Human Platelet-derived growth factor receptor alpha (PDGFRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDGFRA Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017712RA CSB-EP017712RA CSB-BP017712RA CSB-MP017712RA CSB-EP017712RA-B |
Recombinant Rat Platelet-derived growth factor receptor alpha (Pdgfra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDGFRA Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017712MO CSB-EP017712MO CSB-BP017712MO CSB-EP017712MO-B |
Recombinant Mouse Platelet-derived growth factor receptor alpha (Pdgfra), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
PDGFRA Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP326307XBE CSB-EP326307XBE CSB-BP326307XBE CSB-MP326307XBE CSB-EP326307XBE-B |
Recombinant Xenopus laevis Platelet-derived growth factor receptor alpha (pdgfra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDGFRA Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP804293TKY CSB-EP804293TKY CSB-BP804293TKY CSB-MP804293TKY CSB-EP804293TKY-B |
Recombinant Takifugu rubripes Platelet-derived growth factor receptor alpha (pdgfra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDGFRA Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP866765DIL CSB-EP866765DIL CSB-BP866765DIL CSB-MP866765DIL CSB-EP866765DIL-B |
Recombinant Danio rerio Platelet-derived growth factor receptor alpha (pdgfra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDGFRA Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP889488CH CSB-EP889488CH CSB-BP889488CH CSB-MP889488CH CSB-EP889488CH-B |
Recombinant Chicken Platelet-derived growth factor receptor alpha (PDGFRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP017708CH CSB-EP017708CH-B |
Recombinant Chicken Platelet-derived growth factor receptor alpha (PDGFRA) | E.coli In Vivo Biotinylation in E.coli |
PDGFRA ELISA Kit
PDGFRA ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04699m | Mouse Platelet-Derived Growth Factor Soluble Receptor α,PDGFsR-α ELISA kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
