MYL12B
MYL12B是肌球蛋白輕鏈12B的基因編碼的蛋白質(zhì)，它與MYL12A類似，與肌動蛋白重鏈結(jié)合形成肌動蛋白復(fù)合物，共同參與調(diào)控細胞運動等過程。此外，MYL12B的磷酸化狀態(tài)同樣可以影響肌動蛋白復(fù)合物的活性，從而調(diào)節(jié)肌肉收縮強度、細胞運動速度等。 在體外研究中，MYL12B的二磷酸化狀態(tài)可以導(dǎo)致更高的MgATP酶活性和肌球蛋白絲的形成，這對于肌節(jié)蛋白絲的組裝至關(guān)重要。過度表達二磷酸化形式的MYL12B會導(dǎo)致轉(zhuǎn)染的細胞中形成大量肌節(jié)蛋白絲束，而非磷酸化形式的過度表達則會導(dǎo)致肌節(jié)蛋白絲束數(shù)量減少。這表明MYL12B的磷酸化狀態(tài)對于細胞內(nèi)的肌節(jié)蛋白絲和收縮環(huán)的組織具有關(guān)鍵作用。 MYL12B在多種疾病中扮演重要角色。其磷酸化水平與心臟疾病（如心肌損傷、心肌肥厚）和癌癥等相關(guān)，因此，MYL12B同樣有望作為心臟、腫瘤等多種疾病的研究潛力靶點，成為重要的生物學(xué)標志物。
熱銷產(chǎn)品
Recombinant Human Myosin regulatory light chain 12B(MYL12B) (Active)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MYL12B at 2μg/mL can bind Anti-MYL9 recombinant antibody (CSB-RA015318MA1HU)，the EC50 is 7.760-8.646 ng/mL.
MYL12B Antibodies
MYL12B for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA015308GA01HU | MYL12B Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA042133 | MYL12B Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA595808 | MYL12B Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
MYL12B Proteins
MYL12B Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015308RA CSB-EP015308RA CSB-BP015308RA CSB-MP015308RA CSB-EP015308RA-B |
Recombinant Rat Myosin regulatory light chain 12B (Myl12b) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYL12B Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015308BO CSB-EP015308BO CSB-BP015308BO CSB-MP015308BO CSB-EP015308BO-B |
Recombinant Bovine Myosin regulatory light chain 12B (MYL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYL12B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP015308HU-B |
Recombinant Human Myosin regulatory light chain 12B (MYL12B) | In Vivo Biotinylation in E.coli |
| CSB-EP015308HU | Recombinant Human Myosin regulatory light chain 12B (MYL12B) | E.coli |
| CSB-EP015308HUc7 | Recombinant Human Myosin regulatory light chain 12B (MYL12B) (Active) | E.coli |
| CSB-YP015308HU | Recombinant Human Myosin regulatory light chain 12B(MYL12B) | Yeast |
MYL12B Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP661006MO CSB-EP661006MO CSB-BP661006MO CSB-MP661006MO CSB-EP661006MO-B |
Recombinant Mouse Myosin regulatory light chain 12B (Myl12b) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
