IRF7
IRF7，全稱為干擾素調(diào)節(jié)因子7（Interferon Regulatory Factor 7），是人體內(nèi)一種重要的免疫調(diào)節(jié)蛋白。它屬于IRF家族成員，在先天免疫和抗病毒防御中發(fā)揮著關(guān)鍵作用。IRF7蛋白的常見(jiàn)別名包括IMD39、IRF-7、IRF7A、IRF7B、IRF7C、IRF7H和IRF-7H等。IRF7蛋白主要表達(dá)于淋巴組織，如脾臟和淋巴結(jié)，并在病毒感染時(shí)被誘導(dǎo)表達(dá)。它參與調(diào)控I型干擾素的產(chǎn)生，I型干擾素是一類重要的抗病毒細(xì)胞因子，能夠激活下游信號(hào)通路，增強(qiáng)細(xì)胞的抗病毒能力。IRF7蛋白通過(guò)與病毒感染相關(guān)的DNA或RNA結(jié)合，激活下游基因的轉(zhuǎn)錄，從而促進(jìn)I型干擾素的產(chǎn)生。
IRF7蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān)。研究表明，IRF7蛋白的異常表達(dá)或功能缺陷可能與免疫缺陷、病毒感染、腫瘤等疾病相關(guān)。例如，IRF7蛋白的缺失會(huì)導(dǎo)致機(jī)體對(duì)病毒的易感性增加，從而引發(fā)嚴(yán)重的病毒感染。此外，IRF7蛋白還可能參與腫瘤的發(fā)生發(fā)展，其表達(dá)水平與腫瘤細(xì)胞的增殖、凋亡和轉(zhuǎn)移密切相關(guān)。
針對(duì)IRF7蛋白的藥物研發(fā)也取得了一定的進(jìn)展。目前，一些研究機(jī)構(gòu)正在開(kāi)發(fā)針對(duì)IRF7蛋白的抑制劑，以期用于治療病毒感染和腫瘤等疾病。例如，有研究表明，IRF7蛋白的抑制劑可以有效地抑制I型干擾素的產(chǎn)生，從而減輕病毒感染引起的免疫反應(yīng)。此外，IRF7蛋白的抑制劑還可能用于治療某些類型的腫瘤，其作用機(jī)制可能是通過(guò)抑制腫瘤細(xì)胞的增殖和轉(zhuǎn)移來(lái)實(shí)現(xiàn)的。
熱銷產(chǎn)品
Recombinant Human Interferon regulatory factor 7 (IRF7) (CSB-EP011822HU)
驗(yàn)證數(shù)據(jù)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011822HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IRF7.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011822HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IRF7.
Recombinant Human Interferon regulatory factor 7 (IRF7) (CSB-EP011822HUa0)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IRF7 Recombinant Monoclonal Antibody (CSB-RA568273A0HU)
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing A549 cells stained with CSB-RA568273A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human Interferon regulatory factor 7(IRF7) ELISA kit (CSB-EL011822HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL011822HU
規(guī)格：96T/48T
靈敏度：5.8 pg/mL
檢測(cè)范圍：23.4 pg/mL-1500 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IRF7 Antibodies
IRF7 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA235826 | IRF7 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA011822LA01HU | IRF7 Antibody | Human | ELISA, IHC, IF |
| CSB-PA011822LB01HU | IRF7 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011822LC01HU | IRF7 Antibody, FITC conjugated | Human | |
| CSB-PA011822LD01HU | IRF7 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA568273A0HU | IRF7 Recombinant Monoclonal Antibody | Human | ELISA, FC |
IRF7 Proteins
IRF7 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011822MO CSB-BP011822MO CSB-MP011822MO CSB-EP011822MO-B |
Recombinant Mouse Interferon regulatory factor 7 (Irf7) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IRF7 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011822HU CSB-BP011822HU CSB-MP011822HU CSB-EP011822HU-B |
Recombinant Human Interferon regulatory factor 7 (IRF7) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011822HU | Recombinant Human Interferon regulatory factor 7 (IRF7) | E.coli |
| CSB-EP011822HUa0 | Recombinant Human Interferon regulatory factor 7 (IRF7) | E.coli |
IRF7 ELISA Kit
IRF7 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011822HU | Human Interferon regulatory factor 7(IRF7) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 5.8 pg/mL |
