INSR
INSR，全稱胰島素受體，也被稱為CD220，是一種跨膜受體，由胰島素激活。該蛋白屬于蛋白激酶超家族，以四聚體形式存在，由兩個(gè)α亞基和兩個(gè)β亞基通過(guò)二硫鍵連接。α和β亞基由單個(gè)INSR基因編碼，β亞基穿過(guò)細(xì)胞膜。作為胰島素的受體，INSR在細(xì)胞內(nèi)與IRS1（胰島素受體底物1）和磷脂酰肌醇3'-激酶（PI3K）等下游介質(zhì)結(jié)合，通過(guò)磷酸化IRS1激活PI3K-AKT/PKB通路，促進(jìn)葡萄糖攝取和利用，從而調(diào)節(jié)血糖水平。INSR還與IGF1R結(jié)合，形成雜交受體，參與IGF1的信號(hào)轉(zhuǎn)導(dǎo)。INSR的缺陷會(huì)導(dǎo)致Rabson-Mendenhall綜合征、胰島素抵抗、萊普查恩氏癥和家族性高胰島素血癥等疾病。目前，針對(duì)INSR的藥物研發(fā)主要集中在胰島素類似物和受體激動(dòng)劑，如Epichem/Curtin University研發(fā)的INSR激動(dòng)劑EPL-BQ70，用于治療糖尿病。此外，INSR抑制劑的研究也在進(jìn)行中，旨在通過(guò)抑制INSR活性來(lái)治療腫瘤等疾病。
熱銷產(chǎn)品
Recombinant Human Insulin receptor (INSR), partial (Active) (CSB-MP011753HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Human INSR at 2 μg/ml can bind Anti-INSR recombinant antibody (CSB-RA011753MA1HU).The EC50 is 6.703-9.229 ng/mL.
Recombinant Human Insulin receptor (INSR),Partial (CSB-EP011753HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
INSR Recombinant Monoclonal Antibody (CSB-RA155156A0HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescence staining of MCF7 Cells with CSB-RA155156A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
INSR Antibodies
INSR for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011753GA01HU | INSR Antibody | Human,Rat | ELISA,WB,IP |
| CSB-PA202534 | Phospho-INSR (Tyr1361) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA203919 | Phospho-INSR (Tyr1355) Antibody | Human | ELISA,WB |
| CSB-PA945193 | INSR (Ab-1375) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA994563 | Phospho-INSR (Thr1375) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA003043 | INSR Antibody | Human,Mouse,Rat,Monkey | WB, ELISA |
| CSB-PA011224 | Phospho-INSR (T1375) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA011225 | Phospho-INSR (Y1355) Antibody | Human | WB, IHC, ELISA |
| CSB-PA011226 | Phospho-INSR (Y1361) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA011227 | INSR Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA011228 | INSR Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA011229 | INSR Antibody | Human | IHC, IF, ELISA |
| CSB-PA410086 | INSR Antibody | Human | IHC,ELISA |
| CSB-PA011753LA01HU | INSR Antibody | Human | ELISA, IHC, IF |
| CSB-PA011753LB01HU | INSR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011753LC01HU | INSR Antibody, FITC conjugated | Human | |
| CSB-PA011753LD01HU | INSR Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA155156A0HU | INSR Recombinant Monoclonal Antibody | Human | ELISA, IF |
INSR Proteins
INSR Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011753MO1 CSB-EP011753MO1 CSB-BP011753MO1 CSB-MP011753MO1 CSB-EP011753MO1-B |
Recombinant Mouse Insulin receptor (Insr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INSR Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011753RA CSB-EP011753RA1 CSB-BP011753RA1 CSB-MP011753RA1 CSB-EP011753RA-B |
Recombinant Rat Insulin receptor (Insr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INSR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011753HU CSB-BP011753HU CSB-EP011753HU-B |
Recombinant Human Insulin receptor (INSR), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF011753HU(A4) | Recombinant Human Insulin receptor (INSR) | in vitro E.coli expression system |
| CSB-EP011753HU | Recombinant Human Insulin receptor (INSR),Partial | E.coli |
| CSB-MP011753HU | Recombinant Human Insulin receptor (INSR), partial (Active) | Mammalian cell |
INSR Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011753XBE CSB-EP011753XBE CSB-BP011753XBE CSB-MP011753XBE CSB-EP011753XBE-B |
Recombinant Xenopus laevis Insulin receptor (insr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INSR Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011753MOW CSB-EP011753MOW CSB-BP011753MOW CSB-MP011753MOW CSB-EP011753MOW-B |
Recombinant Macaca mulatta Insulin receptor (INSR) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
