GUCY2C
GUCY2C，即鳥(niǎo)苷酸環(huán)化酶2C，別名GC-C、STaR、DIAR6、GUC2C、MECIL、MUCIL等。這是一種在人體中由GUCY2C基因編碼的跨膜蛋白，屬于受體鳥(niǎo)苷酸環(huán)化酶家族。GUCY2C主要在腸上皮細(xì)胞中表達(dá)，其蛋白結(jié)構(gòu)由細(xì)胞外配體結(jié)合結(jié)構(gòu)域、跨膜結(jié)構(gòu)域、細(xì)胞質(zhì)結(jié)構(gòu)域、催化區(qū)和羧基末端區(qū)域組成。GUCY2C的作用機(jī)制是通過(guò)其配體，如鳥(niǎo)苷素、尿鳥(niǎo)苷素以及熱穩(wěn)定性腸毒素STa的結(jié)合，激活GUCY2C，進(jìn)而催化細(xì)胞內(nèi)第二信使環(huán)磷酸鳥(niǎo)苷（cGMP）的產(chǎn)生，這一過(guò)程在調(diào)節(jié)體內(nèi)平衡、維持腸道屏障功能和發(fā)揮抗炎作用中發(fā)揮重要作用。GUCY2C的異常表達(dá)與多種疾病相關(guān)，包括家族性腹瀉、胎糞性腸梗阻、結(jié)直腸癌等。
熱銷(xiāo)產(chǎn)品
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) (CSB-MP010053HUd9)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized human GUCY2C at 5 μg/ml can bind Anti-GUCY2C recombinant antibody (CSB-RA010053A2HU), the EC50 is 3.049-4.660 ng/mL.
GUCY2C Recombinant Monoclonal Antibody (CSB-RA010053A3HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of Human GUCY2C with Anti-GUCY2C recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GUCY2C (CSB-MP010053HU) at 5 μg/mL can bind Anti-GUCY2C recombinant antibody, the EC50 is 5.630-9.996 ng/mL.
T84 cells were stained with Human IgG (green line) and anti-GUCY2C antibody (red line) (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
Untransfected CT26 cells surface (green line) and transfected Human GUCY2C CT26 stable cells surface (red line) were stained with anti-GUCY2C antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
GUCY2C Antibodies
GUCY2C for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA010053LA01HU | GUCY2C Antibody | Human | ELISA, WB |
| CSB-PA010053LB01HU | GUCY2C Antibody, HRP conjugated | Human | ELISA |
| CSB-PA010053LC01HU | GUCY2C Antibody, FITC conjugated | Human | |
| CSB-PA010053LD01HU | GUCY2C Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA010053A2HU | GUCY2C Recombinant Monoclonal Antibody | Human | ELISA, FC |
| CSB-RA010053A3HU | GUCY2C Recombinant Monoclonal Antibody | Human | ELISA, FC |
GUCY2C Proteins
GUCY2C Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010053GU CSB-EP010053GU CSB-BP010053GU CSB-MP010053GU CSB-EP010053GU-B |
Recombinant Guinea pig Heat-stable enterotoxin receptor (GUCY2C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GUCY2C Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | Yeast |
| CSB-EP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | E.coli |
| CSB-BP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | Baculovirus |
| CSB-MP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | Mammalian cell |
GUCY2C Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010053PI CSB-EP010053PI CSB-BP010053PI CSB-MP010053PI CSB-EP010053PI-B |
Recombinant Pig Heat-stable enterotoxin receptor (GUCY2C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GUCY2C Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010053HU CSB-EP010053HU CSB-EP010053HU-B |
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP010053HU | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial | Baculovirus |
| CSB-MP010053HU | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) | Mammalian cell |
| CSB-MP010053HUd9 | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) | Mammalian cell |
GUCY2C Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP664972MO CSB-EP664972MO CSB-EP664972MO-B |
Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP664972MO | Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial | Baculovirus |
| CSB-MP664972MO | Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial | Mammalian cell |
