CSF1
Csf1，全稱為Macrophage colony-stimulating factor 1，常見別名包括M-CSF、CSF-1等。該蛋白在免疫系統(tǒng)中扮演著重要角色，能夠促進(jìn)巨噬細(xì)胞的增殖、分化和存活，并調(diào)控其功能。Csf1蛋白通過與細(xì)胞表面的CSF1R（又稱CD115）結(jié)合發(fā)揮生物學(xué)效應(yīng)，參與多種生理過程，如組織修復(fù)、骨代謝平衡維持等。近年來，研究發(fā)現(xiàn)Csf1蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān)，包括腫瘤、免疫疾病和代謝性疾病等。在腫瘤微環(huán)境中，Csf1蛋白能夠招募和極化巨噬細(xì)胞為M2型（促腫瘤表型），促進(jìn)腫瘤血管生成、免疫抑制和轉(zhuǎn)移。因此，Csf1蛋白及其受體CSF1R已成為腫瘤治療的重要靶點。目前，針對Csf1/CSF1R通路的靶向藥物研發(fā)取得了一定的進(jìn)展，部分藥物已進(jìn)入臨床研究階段，為腫瘤治療提供了新的策略。
熱銷產(chǎn)品
Recombinant Human Macrophage colony-stimulating factor 1 (CSF1), partial (Active) (CSB-MP006043HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 2.880-4.115 ng/mL.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/ml can bind Anti-CSF1 recombinant antibody (CSB-RA006043MA1HU). The EC50 is 4.291-4.988 ng/mL.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/ml can bind Human CSF1R protein (CSB-MP006044HU). The EC50 is 37.37-43.34 ng/mL.
CSF1 Recombinant Monoclonal Antibody (CSB-RA006043MA1HU) captured on Protein A Chip can bind Recombinant Human CSF1 protein with an affinity constant of 0.13 nM as detected by MetaSPR Assay (WeSPRTM 200).
Recombinant Human Macrophage colony-stimulating factor 1 (CSF1), partial (Active) (CSB-YP006043HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 0.5913-1.205 ng/mL.
The purity of CSF1 was greater than 90% as determined by SEC-HPLC
Recombinant Human Macrophage colony-stimulating factor 1 (CSF1), partial (Active) (CSB-MP006043HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 2.880-4.115 ng/mL.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/ml can bind Anti-CSF1 recombinant antibody (CSB-RA006043MA1HU). The EC50 is 4.291-4.988 ng/mL.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/ml can bind Human CSF1R protein (CSB-MP006044HU). The EC50 is 37.37-43.34 ng/mL.
CSF1 Recombinant Monoclonal Antibody (CSB-RA006043MA1HU) captured on Protein A Chip can bind Recombinant Human CSF1 protein with an affinity constant of 0.13 nM as detected by MetaSPR Assay (WeSPRTM 200).
Recombinant Mouse Macrophage colony-stimulating factor 1 (Csf1), partial (Active) (CSB-MP006043MO)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Mouse Csf1 at 2 μg/ml can bind Mouse Csf1r(CSB-MP006044MO). The EC50 is 3.226-4.264 ng/mL.
The purity of Csf1 was greater than 90% as determined by SEC-HPLC
驗證數(shù)據(jù)
CSF1 Antibody (CSB-PA06859A0Rb)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA06859A0Rb at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA06859A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Macrophage Colony-Stimulating Factor,M-CSF ELISA kit (CSB-E04658h)
驗證數(shù)據(jù)
貨號：CSB-E04658h
規(guī)格：96T/48T
靈敏度：0.039 ng/ml
檢測范圍：0.156 ng/ml - 10 ng/ml
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CSF1 Antibodies
CSF1 for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA07777A0Rb | Csf1 Antibody | Mouse | ELISA |
| CSB-PA07779A0Rb | Csf1 Antibody | Mouse | ELISA, IHC |
CSF1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA06859A0Rb | CSF1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA006115 | CSF1 Antibody | Human | WB, ELISA |
CSF1 Proteins
CSF1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP006043MO CSB-BP006043MO CSB-EP006043MO-B |
Recombinant Mouse Macrophage colony-stimulating factor 1 (Csf1), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP006043MO | Recombinant Mouse Macrophage colony-stimulating factor 1 (Csf1), partial | E.coli |
| CSB-AP003461MO | Recombinant Mouse Macrophage colony-stimulating factor 1 protein (Csf1), partial (Active) | E.Coli |
| CSB-CF006043MO(A4) | Recombinant Mouse Macrophage colony-stimulating factor 1 (Csf1) | in vitro E.coli expression system |
| CSB-AP003641MO | Recombinant Mouse Macrophage colony-stimulating factor 1 (Csf1), partial (Active) | Mammalian cell |
CSF1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP613201SVG CSB-EP613201SVG CSB-BP613201SVG CSB-MP613201SVG CSB-EP613201SVG-B |
Recombinant Saccharomyces cerevisiae Protein CSF1 (CSF1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF1 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP765584DOT CSB-EP765584DOT CSB-BP765584DOT CSB-MP765584DOT CSB-EP765584DOT-B |
Recombinant Ashbya gossypii Protein CSF1 (CSF1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP810353RA CSB-BP810353RA CSB-MP810353RA CSB-EP810353RA-B |
Recombinant Rat Macrophage colony-stimulating factor 1 (Csf1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF1 Proteins for Homo sapiens (Human)
CSF1 ELISA Kit
CSF1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04658h | Human Macrophage Colony-Stimulating Factor,M-CSF ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/ml |
CSF1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04659m | Mouse Macrophage Colony-Stimulating Factor,M-CSF ELISA kit | serum, plasma, tissue homogenates | 1.95 pg/mL |
CSF1 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07424r | Rat Macrophage Colony-Stimulating Factor,M-CSF ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.039 ng/ml |
