CD55
CD55，也被稱為衰變加速因子（DAF），是一種重要的補(bǔ)體調(diào)節(jié)蛋白，在人體內(nèi)發(fā)揮著關(guān)鍵的免疫保護(hù)作用。它屬于RCA（補(bǔ)體激活調(diào)節(jié)蛋白）家族，含有4到30個(gè)短共識(shí)重復(fù)（SCR）結(jié)構(gòu)域，通過這些結(jié)構(gòu)域參與多種生物過程。CD55主要通過抑制補(bǔ)體系統(tǒng)的激活來保護(hù)細(xì)胞免受攻擊。它能夠識(shí)別補(bǔ)體系統(tǒng)產(chǎn)生的C3b和C4b片段，通過與C4b結(jié)合抑制C2轉(zhuǎn)化為C2b，進(jìn)而阻止C4b2a形成C3轉(zhuǎn)化酶，從而抑制C3轉(zhuǎn)化酶的形成。在替代途徑中，CD55與C3b結(jié)合后可以干擾D因子將B因子轉(zhuǎn)化為Bb，同樣阻止膜攻擊復(fù)合物的形成。CD55的這些作用機(jī)制有效地防止了補(bǔ)體級(jí)聯(lián)反應(yīng)的過度激活，保護(hù)細(xì)胞免受補(bǔ)體攻擊。此外，CD55還參與腫瘤的發(fā)生發(fā)展，在多種癌癥中高表達(dá)，如前列腺癌、宮頸癌、乳腺癌等。CD55與CD97結(jié)合形成的復(fù)合物在腫瘤細(xì)胞的分化、遷移、浸潤及轉(zhuǎn)移中發(fā)揮重要作用。基于CD55在免疫系統(tǒng)和腫瘤生物學(xué)中的重要作用，CD55和CD97成為癌癥治療研究的新興靶點(diǎn)。目前，已有多種靶向CD55和CD97的藥物正在研發(fā)中，如CD55抗體可用于抑制結(jié)直腸癌和肺癌的惡化，CD55相關(guān)信號(hào)通路的抑制可增強(qiáng)其他治療藥物的抗腫瘤作用。此外，針對(duì)CD55缺乏蛋白丟失性腸病（CHAPLE病）的治療藥物也在研發(fā)中，如FDA已批準(zhǔn)的新藥Veopoz，它是一種C5補(bǔ)體抑制劑，能靶向參與補(bǔ)體系統(tǒng)激活的蛋白質(zhì)補(bǔ)體因子C5，預(yù)防補(bǔ)體途徑介導(dǎo)的CHAPLE病。
熱銷產(chǎn)品
Recombinant Human Complement decay-accelerating factor (CD55), partial (CSB-EP004945HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CD55 Recombinant Monoclonal Antibody (CSB-RA440943A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: A549 whole cell lysate, 293T whole cell lysate, K562 whole cell lysate
All lanes: CD55 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42, 49, 40, 57, 60 kDa
Observed band size: 70 kDa
IHC image of CSB-RA440943A0HU diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA440943A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Human decay-accelerating factor(DAF/CD55)ELISA Kit (CSB-E05121h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E05121h
規(guī)格：96T/48T
靈敏度：0.09 ng/ml
檢測(cè)范圍：0.39 ng/ml- 25ng/ml
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CD55 Antibodies
CD55 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005226 | CD55 Antibody | Human | WB, ELISA |
| CSB-PA004945LA01HU | CD55 Antibody | Human | ELISA, IHC, IF |
| CSB-PA004945LB01HU | CD55 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA440943A0HU | CD55 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
CD55 Proteins
CD55 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004945HU CSB-EP004945HU CSB-BP004945HU CSB-MP004945HU CSB-EP004945HU-B |
Recombinant Human Complement decay-accelerating factor (CD55) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004945HU1 | Recombinant Human Complement decay-accelerating factor (CD55), partial | E.coli |
CD55 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004945EXP CSB-EP004945EXP CSB-BP004945EXP CSB-MP004945EXP CSB-EP004945EXP-B |
Recombinant Pongo pygmaeus Complement decay-accelerating factor (CD55) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD55 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP720250MO CSB-EP720250MO CSB-BP720250MO CSB-MP720250MO CSB-EP720250MO-B |
Recombinant Mouse Complement decay-accelerating factor, GPI-anchored (Cd55) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD55 Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP736710GU CSB-EP736710GU CSB-BP736710GU CSB-MP736710GU CSB-EP736710GU-B |
Recombinant Guinea pig Complement decay-accelerating factor (CD55) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD55 ELISA Kit
CD55 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E05121h | Human decay-accelerating factor(DAF/CD55)ELISA Kit | serum, plasma, tissue homogenates | 0.09 ng/ml |
