CD44
CD44是一種細(xì)胞表面I型跨膜糖蛋白，屬于黏附分子家族。CD44包括標(biāo)準(zhǔn)亞型（CD44s）和CD44變異亞型（CD44v）。CD44作為一種廣譜表達(dá)的細(xì)胞粘附分子，參與細(xì)胞增殖、分化、遷移，血管生成等生物學(xué)過(guò)程，對(duì)于介導(dǎo)細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)，調(diào)節(jié)組織穩(wěn)態(tài)等功能具有關(guān)鍵作用。CD44也被認(rèn)為是一種整合跨膜糖蛋白，能夠接受細(xì)胞微環(huán)境的細(xì)胞因子的作用，將接收的信號(hào)進(jìn)行整合，通過(guò)裂解酶的作用釋放CD44胞內(nèi)域，將其信號(hào)傳到細(xì)胞核。CD44也是公認(rèn)的腫瘤干細(xì)胞的標(biāo)志物，是上皮細(xì)胞間充質(zhì)轉(zhuǎn)化（EMT）關(guān)鍵調(diào)節(jié)因子，參與腫瘤的發(fā)生，進(jìn)展和轉(zhuǎn)移。近年來(lái)，越來(lái)越多的研究發(fā)現(xiàn)CD44與多種腫瘤的發(fā)生、生長(zhǎng)、侵襲、轉(zhuǎn)移和預(yù)后密切相關(guān)。
Recombinant Human CD44 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)
SDS-PAGE
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(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Measured by its binding ability in a functional ELISA. Immobilized CD44 at 2 μg/ml can bind Anti-CD44 mouse monoclonal antibody(CSB-MA004938A0m, antigen from E.coli), the EC50 of the CD44 protein is 11.89-14.94 ng/ml.
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Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP004938HU(F1) could indicate that this peptide derived from Mammalian Cell-expressed Homo sapiens (Human) CD44.
CD44 Antibodies
CD44 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004938GA01HU | CD44 Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA644696 | CD44 Antibody | Human,Rat | ELISA,WB,IF |
| CSB-PA135522 | Phospho-CD44 (Ser706) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA001460 | CD44 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA080035 | Phospho-CD44 (S706) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA282285 | CD44 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA685145 | CD44 Antibody | Human | ELISA,WB |
| CSB-PA191560 | CD44 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA004938A0HU | CD44 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-MA004938A0m | CD44 Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
| CSB-MA247417 | CD44 Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA292372A0HU | CD44 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
| CSB-RA004938MA1HU | CD44 Recombinant Monoclonal Antibody | Human | ELISA, FC |
CD44 Proteins
CD44 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004938MO1 CSB-EP004938MO1 CSB-BP004938MO1 CSB-MP004938MO1 CSB-EP004938MO1-B |
Recombinant Mouse CD44 antigen (Cd44), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004938MO | Recombinant Mouse CD44 antigen (Cd44) | in vitro E.coli expression system |
CD44 Proteins for Homo sapiens (Human)
CD44 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004938RA1 CSB-EP004938RA1 CSB-BP004938RA1 CSB-MP004938RA1 CSB-EP004938RA1-B |
Recombinant Rat CD44 antigen (Cd44), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004938RA | Recombinant Rat CD44 antigen (Cd44) | in vitro E.coli expression system |
CD44 Proteins for Papio hamadryas (Hamadryas baboon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004938ERJ1 CSB-EP004938ERJ1 CSB-BP004938ERJ1 CSB-MP004938ERJ1 CSB-EP004938ERJ1-B |
Recombinant Papio hamadryas CD44 antigen (CD44), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004938ERJ | Recombinant Papio hamadryas CD44 antigen (CD44) | in vitro E.coli expression system |
CD44 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004938DXU1 CSB-EP004938DXU1 CSB-BP004938DXU1 CSB-MP004938DXU1 CSB-EP004938DXU1-B |
Recombinant Cricetulus griseus CD44 antigen (CD44), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004938DXU | Recombinant Cricetulus griseus CD44 antigen (CD44) | in vitro E.coli expression system |
CD44 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP635685DO CSB-EP635685DO CSB-BP635685DO CSB-MP635685DO CSB-EP635685DO-B |
Recombinant Dog CD44 antigen (CD44), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD44 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP643679BO CSB-EP643679BO CSB-BP643679BO CSB-MP643679BO CSB-EP643679BO-B |
Recombinant Bovine CD44 antigen (CD44), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD44 Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP723318MRG CSB-EP723318MRG CSB-BP723318MRG CSB-MP723318MRG CSB-EP723318MRG-B |
Recombinant Mesocricetus auratus CD44 antigen (CD44), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD44 ELISA Kit
CD44 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11846h | Human cluster Of differentiation,CD44 ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 19.5 pg/mL |
