CD276

CD276，別名B7H3、B7-H3、4Ig-B7-H3，是一種I型跨膜蛋白，屬于B7家族成員之一，主要表達于抗原呈遞細胞表面。
其作用機制涉及與T細胞共刺激分子家族成員相互作用，激活或抑制T細胞的活化與增殖。CD276既可以作為共刺激因子促進T細胞激活、增殖和細胞因子分泌，也可能在某些適應性免疫應答中起到共抑制作用，使腫瘤逃避免疫反應和抑制NK細胞介導的細胞裂解。
CD276在多種腫瘤中表達，并與腫瘤的發生、侵襲和轉移有關，是一種重要的免疫檢查點分子和潛在的腫瘤免疫治療靶點。

熱銷產品

Recombinant Human CD276 antigen (CD276), partial (Active) (CSB-MP733578HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC₅₀ of human CD276 protein is 1.961-2.243 ng/ml.

Recombinant Macaca fascicularis CD276 molecule(CD276),partial (Active) (CSB-MP5140MOV)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CD276 at 2 μg/ml can bind Anti-CD276 recombinant antibody(CSB-RA733578MA1HU). The EC₅₀ is 4.299-5.373 ng/mL.

The purity of CD276 was greater than 90% as determined by SEC-HPLC

CD276 Recombinant Monoclonal Antibody (CSB-RA733578MA1HU)

驗證數據

The Binding Activity of Human CD276 with Anti-CD276 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD276(CSB-MP5140MOV) at 2 μg/mL can bind Anti-CD276 recombinant antibody. The EC₅₀ is 4.299-5.373 ng/mL.

The Binding Activity of Human CD276 with Anti-CD276 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD276(CSB-MP733578HU(F2)) at 2 μg/mL can bind Anti-CD276 recombinant antibody. The EC₅₀ is 47.12-54.16 ng/mL.

Overlay Peak curve showing MCF7 cells stained with CSB-RA733578MA1HUMA1HU (red line) at 1:100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

CD276 Antibody

CD276 Protein

CD276 ELISA Kit

CD276 Antibodies

CD276 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA004912GA01HU	CD276 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA005320	CD276 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA745871ESR1HU	CD276 Antibody	Human	ELISA, WB, IHC
CSB-PA745871ESR2HU	CD276 Antibody	Human	ELISA, IHC
CSB-RA733578MA1HU	CD276 Recombinant Monoclonal Antibody	Human, Cynomolgus	ELISA, FC

CD276 Proteins

CD276 Proteins for Xenopus laevis (African clawed frog)

產品貨號	產品名稱	來源
CSB-YP731567XBE CSB-EP731567XBE CSB-BP731567XBE CSB-MP731567XBE CSB-EP731567XBE-B	Recombinant Xenopus laevis CD276 antigen homolog (cd276), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD276 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP733578HU CSB-EP733578HU CSB-BP733578HU CSB-EP733578HU-B	Recombinant Human CD276 antigen (CD276), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP733578HU	Recombinant Human CD276 antigen (CD276), partial (Active)	Mammalian cell
CSB-MP733578HU-B	Recombinant Human CD276 antigen (CD276), partial, Biotinylated	Mammalian cell
CSB-MP733578HU(F2)	Recombinant Human CD276 antigen (CD276), partial (Active)	Mammalian cell
CSB-MP733578HU(A4)f4	Recombinant Human CD276 antigen (CD276)-VLPs	Mammalian cell

CD276 Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP745871RA CSB-EP745871RA CSB-BP745871RA CSB-MP745871RA CSB-EP745871RA-B	Recombinant Rat CD276 antigen (Cd276), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD276 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP848693MO CSB-EP848693MO CSB-BP848693MO CSB-EP848693MO-B	Recombinant Mouse CD276 antigen (Cd276), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli