ADAM17
ADAM17（解整合素金屬蛋白酶17）又稱TACE（腫瘤壞死因子α轉化酶），是一種跨膜蛋白酶，主要參與細胞表面蛋白的裂解和信號傳導調控。ADAM17通過剪切多種膜錨定分子（如TNF-α、EGFR配體及Notch受體等），在炎癥反應、表皮生長及免疫調節中發揮關鍵作用。其活性異常與類風濕性關節炎、銀屑病等自身免疫疾病密切相關，同時也在結直腸癌、乳腺癌等惡性腫瘤的侵襲轉移過程中起促進作用。近年來研究發現，ADAM17可通過激活EGFR信號通路加速腫瘤細胞增殖，并與阿爾茨海默病中淀粉樣蛋白前體的加工存在潛在關聯。
針對ADAM17的藥物研發聚焦于抑制其蛋白酶活性，已有多個小分子抑制劑（如INCB7839、BMS-561392）進入臨床試驗階段，嘗試用于三陰性乳腺癌和急性髓系白血病的治療。單克隆抗體類藥物如MEDI3622則通過阻斷ADAM17與底物結合發揮作用，但部分藥物因影響生理功能而存在安全性問題，其特異性抑制策略和疾病適應癥仍在持續探索中。
熱銷產品
ADAM17 Recombinant Monoclonal Antibody (CSB-RA797631A0HU)
驗證數據
Immunofluorescence staining of Hela Cells with CSB-RA797631A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
ADAM17 Antibodies
ADAM17 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA001277GA01HU | ADAM17 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA050198 | Cleaved-ADAM17 (R215) Antibody | Human | WB, ELISA |
| CSB-PA050199 | Phospho-ADAM17 (T735) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA050200 | ADAM17 Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA261035 | ADAM17 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA797631A0HU | ADAM17 Recombinant Monoclonal Antibody | Human | ELISA, IF |
ADAM17 Proteins
ADAM17 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP001277HU1 CSB-EP001277HU1 CSB-BP001277HU1 CSB-MP001277HU1 CSB-EP001277HU1-B |
Recombinant Human Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001277HU | Recombinant Human Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | in vitro E.coli expression system |
ADAM17 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP001277PI CSB-EP001277PI CSB-BP001277PI CSB-MP001277PI CSB-EP001277PI-B |
Recombinant Pig Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADAM17 ELISA Kit
ADAM17 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09315h | Human TNF α converting enzyme,TACE ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 15.6 pg/mL |
ADAM17 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL001277MO | Mouse Disintegrin and metalloproteinase domain-containing protein 17(ADAM17) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
