Recombinant Chicken Growth hormone receptor (GHR)

in vitro E.coli expression system

中文名稱：

雞GHR重組蛋白
貨號：

CSB-CF009411CH
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

GHR
Uniprot No.：

Q02092
別名：

GHR; Growth hormone receptor; GH receptor; Somatotropin receptor
種屬：

Gallus gallus (Chicken)
蛋白長度：

Full Length of Mature Protein
表達區域：

17-608
氨基酸序列

DSLSASDDLLQWPQISKCRSPELETFSCYWTDGKVTTSGTIQLLYMKRSDEDWKECPDYITAGENSCYFNTSYTSIWIPYCVKLANKDEVFDEKCFSVDEIVLPDPPVHLNWTLLNTSQTGIHGDIQVRWDPPPTADVQKGWITLEYELQYKEVNETKWKELEPRLSTVVPLYSLKMGRDYEIRVRSRQRTSEKFGEFSEILYVSFTQAGIEFVHCAEEIEFPWFLVVVFGVCGLAVTAILILLSKQPRLKMLIFPPVPVPKIKGIDPDLLKKGKLDEVNSILASHDNYKTQLYNDDLWVEFIELDIDDSDEKNRVSDTDRLLSDDHLKSHSCLGAKDDDSGRASCYEPDIPETDFSASDTCDAISDIDQFKKVTEKEEDLLCLHRKDDVEALQSLANTDTQQPHTSTQSESRESWPPFADSTDSANPSVQTQLSNQNSLTNTDFYAQVSDITPAGSVVLSPGQKSKVGRAQCESCTEQNFTMDNAYFCEADVKKCIAVISQEEDEPRVQEQSCNEDTYFTTESLTTTGINLGASMAETPSMEMPVPDYTSIHIVHSPQGLVLNATALPVPEKEFNMSCGYVSTDQLNKIMP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
基因功能參考文獻：
1. the molecular mechanisms underlying growth hormone receptor (GHR) in Sex-linked dwarf chickens, was examined. PMID: 27819736
2. GHR mRNA was expressed in all examined oviductal segments with a significantly lower level in the infundibulum in comparison to other parts of the oviduct; specific GHR immunoreactivity was also detected in the wall of the oviduct. PMID: 24279179
3. Between 3 and 6 wk of age, growth hormone receptor expression increased with age in adipose tissue. PMID: 22560177
4. There is a critical miRNA, let-7b, involved in the regulation of GHR. PMID: 22781587
5. Pectoralis major muscle GHR mRNA was greater in line of low weight than high weight selected chicken. PMID: 21500111
6. These results support the possibility that GH acts as a local growth factor during early embryonic development of the visual system. PMID: 17618059
7. The expression of GHR gene was more than 3-fold higher in dwarf chickens, compared with that of the normal. PMID: 17681929
8. Growth hormone (GH) receptor mRNA was also detected within cells of the E7 retinal ganglion cells (RGC) layer and GH receptor protein colocalized with GH in RGC axons. PMID: 19213842
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相關疾病：

Defects in GHR are a cause of sex-linked dwarf chicken. A restriction fragment length polymorphism, and an aberrantly-sized transcript in liver leads to a GHR with undetectable GH-binding activity causing growth deficiency and other endocrine abnormalities.
亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway.
蛋白家族：

Type I cytokine receptor family, Type 1 subfamily
組織特異性：

Broad specificity.
數據庫鏈接：

KEGG: gga:408184

STRING: 9031.ENSGALP00000032222

UniGene: Gga.9233