Recombinant Rat TNF receptor-associated factor 6 (Traf6)

中文名稱：

大鼠Traf6重組蛋白
貨號(hào)：

CSB-YP024154RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Traf6重組蛋白
貨號(hào)：

CSB-EP024154RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Traf6重組蛋白
貨號(hào)：

CSB-EP024154RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Traf6重組蛋白
貨號(hào)：

CSB-BP024154RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Traf6重組蛋白
貨號(hào)：

CSB-MP024154RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Traf6
Uniprot No.：

B5DF45
別名：

Traf6; TNF receptor-associated factor 6; EC 2.3.2.27; E3 ubiquitin-protein ligase TRAF6; RING-type E3 ubiquitin transferase TRAF6
種屬：

Rattus norvegicus (Rat)
蛋白長(zhǎng)度：

Full length protein
表達(dá)區(qū)域：

1-530
氨基酸序列

MSLLNCENSC ASSQSSSDCC AAMANSCSAA MKDDSVSGCV STGNLSSSFM EEIQGYDVEF DPPLESKYEC PICLMALREA VQTPCGHRFC KACITKSIRD AGHKCPVDNE ILLENQLFPD NFAKREILSL TVKCPNKGCV QKMELRHLED HQVHCEFALV ICPQCQRFFQ KCQINKHIIE DCPRRQVSCV NCAVPMPYEE KEIHDQSCPL ANIICEYCGT ILIREQMPNH YDLDCPTAPV PCTFSVFGCH EKMQRNHLAR HLQENTQLHM RLLAQAVHNV NLSLRPCDAS SPSRGCRPED PNYEETVKQL EGRLVRQDHQ IRELTAKMET QSMHVSELKR TIRSLEDKVA EMEAQQCNGI YIWKIGNFGM HLKSQEEERP VVIHSPGFYT GRPGYKLCMR LHLQLPTAQR CANYISLFVH TMQGEYDSHL PWPFQGTIRL TILDQSEAVI RQNHEEVMDA KPELLAFQRP TIPRNPKGFG YVTFMHLEAL RQGTFIKDDT LLVRCEVSTR FDMGGLRKEG FQPRSTDAGV
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
基因功能參考文獻(xiàn)：
1. miR-194 can inhibit lipopolysaccharide-induced inflammatory response in nucleus pulposus cells of the intervertebral disc (IVD) by targeting TRAF6. PMID: 29745371
2. showed that application of TRAF6 over-expression plasmid and genetic silencing siRNA could increase or decrease expression of TRAF6, respectively, and severely exacerbate or relieve EBI after SAH, including neuronal death, brain edema, and blood-brain barrier injury PMID: 28543180
3. Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors PMID: 27813153
4. As a negative feedback element, miRNA-146a could make sure that the expression of IRAK1- and TRAF6-mediated genes was under tight control. Thus, miRNA-146a may serve as a novel therapeutic target for SCI interventions. PMID: 27830143
5. increased in the heart of diabetic rats PMID: 26925748
6. TRAF6 is involved in the pathophysiological process induced by cerebral ischemia-reperfusion and functions partially as a pro-inflammatory adaptor to mediate cell apoptosis. PMID: 23001490
7. TRAF6 might play important roles in central nervous system pathophysiology after traumatic brain injury. PMID: 21072581
8. Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells. PMID: 20659889
9. TRAF6 knockdown may inhibit inflammatory response and promote cell survival upon lipopolysaccharides in challenge in primary rat proximal renal tubular cells PMID: 20136795
10. findings showed that TRAF6 might be associated with osteoclast differentiation in periapical lesions PMID: 19482181
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亞細(xì)胞定位：

Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet.
蛋白家族：

TNF receptor-associated factor family, A subfamily
數(shù)據(jù)庫鏈接：

KEGG: rno:311245

STRING: 10116.ENSRNOP00000006148

UniGene: Rn.220435