Recombinant Mouse Vitronectin (Vtn)

中文名稱：

小鼠Vtn重組蛋白
貨號：

CSB-YP025944MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Vtn重組蛋白
貨號：

CSB-EP025944MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Vtn重組蛋白
貨號：

CSB-BP025944MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Vtn重組蛋白
貨號：

CSB-MP025944MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Vtn
Uniprot No.：

P29788
別名：

Vtn; Vitronectin; VN; S-protein; Serum-spreading factor
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

20-478
氨基酸序列

D QESCKGRCTQ GFMASKKCQC DELCTYYQSC CADYMEQCKP QVTRGDVFTM PEDDYWSYDY VEEPKNNTNT GVQPENTSPP GDLNPRTDGT LKPTAFLDPE EQPSTPAPKV EQQEEILRPD TTDQGTPEFP EEELCSGKPF DAFTDLKNGS LFAFRGQYCY ELDETAVRPG YPKLIQDVWG IEGPIDAAFT RINCQGKTYL FKGSQYWRFE DGVLDPGYPR NISEGFSGIP DNVDAAFALP AHRYSGRERV YFFKGKQYWE YEFQQQPSQE ECEGSSLSAV FEHFALLQRD SWENIFELLF WGRSSDGARE PQFISRNWHG VPGKVDAAMA GRIYVTGSLS HSAQAKKQKS KRRSRKRYRS RRGRGHRRSQ SSNSRRSSRS IWFSLFSSEE SGLGTYNNYD YDMDWLVPAT CEPIQSVYFF SGDKYYRVNL RTRRVDSVNP PYPRSIAQYW LGCPTSEK
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
基因功能參考文獻(xiàn)：
1. The effects of genetic alterations in PAI-1 expression, pharmacologic PAI-1 inhibition and recombinant PAI-1 on smooth muscle cell vitronectin (VN) expression were studied, and vascular VN expression in wild-type and PAI-1-deficient mice was assessed. PMID: 29028290
2. this study demonstrates in a mouse infection model that Vn reduces complement-mediated killing of Yersinia enterocolitica O:9 E40 and, thus, improves bacterial survival PMID: 27798934
3. the TGF-beta-PAI-1-vitronectin-integrin axis may represent a critical convergence of factors in determining the alveolar epithelial cell apoptotic response during lung injury. PMID: 27106291
4. In vtn knockout mice, neuronal differentiation in the cerebellum was suppressed compared with wild-type mice. PMID: 26640242
5. PAI-1, through its interaction with Vn, exerts multiple deleterious mechanisms to induce AKI. PMID: 25799354
6. These data suggest that adhesion to vitronectin allows for the uncoupling of fibronectin fibril formation from downstream signaling events by reducing alpha5beta1 integrin activation and fibronectin fibril extension. PMID: 24509439
7. Report role of vitronectin in the regulation of angiogenesis induced by VEGF. PMID: 24603119
8. Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages. PMID: 23345331
9. VN plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on VE-cadherin trafficking. PMID: 22606350
10. ability of vitronectin to enhance neutrophil viability was dependent on activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 kinases, but not on the p38 kinase PMID: 22281987
11. These results demonstrate that vitronectin exerts a deleterious role independently from complement, by directing PAI-dependent fibrinolysis in the glomerular compartment. PMID: 21764994
12. the vitronectin-binding capacity of PAI-1 was the primary determinant required for its ability to exacerbate lung scarring induced by intratracheal bleomycin administration PMID: 21734232
13. Suggest that despite significant interstitial Vtn deposition in the ureteral obstruction model of chronic kidney disease, its fibrogenic role is either nonessential or redundant. PMID: 21270094
14. Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices PMID: 20492459
15. Endogenous vitronectin promotes neointima formation in carotid arteries. PMID: 12067901
16. regulation of cell spreading on vitronectin by ERK1 association with alphaVbeta3 integrin PMID: 12393886
17. In a carotid artery ligation model, vitronectin (VN) knockout mice generate a larger intima than wild-type as a result of more extensive smooth muscle cell (SMC)proliferation, demonstrating that VN inhibits thrombin-mediated SMC proliferation. PMID: 12482822
18. vitronectin can selectively regulate inactivating potassium current in embryonic hippocampal neurons PMID: 12562917
19. competition with plasminogen activator inhibitor type-1 for alphavbeta3 binding inhibits insulin signaling PMID: 12603314
20. in contrast to released platelet granule Vn which enhances platelet aggregation, plasma Vn inhibits platelet aggregation PMID: 15733060
21. There is an increase of vitronectin and integrin alphav in the retina and the optic nerve after optic nerve injury. Induction of Vitronectin and integrin alphav may have an important role in the regeneration of adult mammalian retinal ganglion cells. PMID: 16479252
22. PrP(C) plays an important role in axonal growth, and this function may be rescued in PrP(C)-knockout animals by integrin compensatory mechanisms. PMID: 17504807
23. a novel vitronectin-dependent mechanism contributing to the development of acute lung injury. PMID: 17982099
24. VN is a key determinant of the antiproliferative effect of PAI-1 overexpression. PMID: 19574558
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亞細(xì)胞定位：

Secreted, extracellular space.
組織特異性：

Plasma.
數(shù)據(jù)庫鏈接：

KEGG: mmu:22370

STRING: 10090.ENSMUSP00000017488

UniGene: Mm.3667