Recombinant Mouse Receptor activity-modifying protein 2 (Ramp2), partial

中文名稱：

小鼠Ramp2重組蛋白
貨號：

CSB-YP892990MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Ramp2重組蛋白
貨號：

CSB-EP892990MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Ramp2重組蛋白
貨號：

CSB-EP892990MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ramp2重組蛋白
貨號：

CSB-BP892990MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ramp2重組蛋白
貨號：

CSB-MP892990MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ramp2
Uniprot No.：

Q9WUP0
別名：

Ramp2; Receptor activity-modifying protein 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
基因功能參考文獻：
1. The AM-RAMP2 system exerts crucial vasoprotective effects after vascular injury and could be a therapeutic target for the treatment of vascular diseases. PMID: 28324104
2. Results provide in vivo evidence of a role for RAMP2 in placental development distinct from the RAMP2-calcitonin receptor-like receptor/adrenomedullin signaling paradigm; decreases Pthr1 expression and causes a blunted response to systemic parathyroid hormone; and identify additional pathways underlying the endocrine and fertility defects of the previously characterized Ramp2 heterozygous adult females. PMID: 28727763
3. the Adrenomedullin-RAMP2 system regulates vascular integrity, whereas RAMP2 deletion promotes vascular permeability PMID: 27307317
4. RAMP2 is essential for early vascular development and knockout-mice die in utero. PMID: 25264174
5. These results indicate the AM-RAMP2 system works to protect nerve cells from both acute and chronic cerebral ischemia by maintaining cerebral blood flow suppressing oxidative stress, and in the case of chronic ischemia, enhancing capillary growth. PMID: 25252154
6. It is not only an angiogenesis factor, but maintains hemostasis of blood vessels and organs. PMID: 24813793
7. The AM-RAMP2 system is a key determinant of vascular integrity and homeostasis from prenatal stages through adulthood. PMID: 23355623
8. These data demonstrate that the adrenomedullin-RAMP2 system is essential for cardiac metabolism and homeostasis. PMID: 23297372
9. Adrenomedullin-RAMP2 system is the potential target for the induction of liver sinusoidal endothelial cells. PMID: 21782867
10. this work reveals an essential role for RAMP2 in endocrine physiology and provides the first in vivo evidence for a physiological role of RAMP2 beyond that of AM/CLR signaling PMID: 21566080
11. expressed in osteoclast-like cells PMID: 15691893
12. RAMP2 plays a key role in the sensitivity and potency of AM-induced hypotensive responses via the AM1 receptor. PMID: 16373602
13. RAMP2 and RAMP3 have distinct physiological functions throughout embryogenesis, adulthood, and old age PMID: 17470425
14. RAMP2 is a key determinant of the effects of AM on the vasculature and is essential for angiogenesis and vascular integrity. PMID: 18097473
15. the vascular smooth muscle AM1 receptor RAMP2 acts at a local level to protect against hypertension-induced vascular hypertrophy and inflammation PMID: 19858409
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

RAMP family
組織特異性：

Ubiquitous. Expressed predominantly in embryonic brain, lung and gut and in adult heart, lung, skeletal muscle and brain.
數據庫鏈接：

KEGG: mmu:54409

STRING: 10090.ENSMUSP00000122072

UniGene: Mm.260698