Recombinant Mouse Hemogen (Hemgn)

中文名稱：

小鼠Hemgn重組蛋白
貨號：

CSB-YP010284MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Hemgn重組蛋白
貨號：

CSB-EP010284MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Hemgn重組蛋白
貨號：

CSB-EP010284MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Hemgn重組蛋白
貨號：

CSB-BP010284MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Hemgn重組蛋白
貨號：

CSB-MP010284MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Hemgn
Uniprot No.：

Q9ERZ0
別名：

Hemgn; Ndr; Hemogen; Hemopoietic gene protein; Negative differentiation regulator protein; mNDR
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-503
氨基酸序列

MDMGKGRPRL KLPQMPEAHP QKSCAPDIIG SWSLRNREQL RKRKAEAQGR QTSQWLLGEQ KKRKYQRTGK GNKRGRKRQG NVEQKAEPWS QTERERVQEV LVSAEEETEH PGNSATEALP LVPSPTKAVP ADQCSEAHQE SIQCQERAIQ NHSQTHLSPT TCQGIAVLQH SPKMCQDMAE PEVFSPNMCQ ETAVPQTYPP KALEEMAAAE PLSPKMCQET TVSPNHSSKV PQDMAGPEAL SPNMCQEPTV PQEHTLKMCH DVARPEVLSP KTHQEMAVPK AFPCVTPGDA AGLEGCAPKA LPQSDVAEGC PLDTTPTSVT PEQTTSDPDL GMAVTEGFFS EARECTVSEG VSTKTHQEAV EPEFISHETY KEFTVPIVSS QKTIQESPEP EQYSPETCQP IPGPENYSLE TCHEMSGPED LSIKTCQDRE EPKHSLPEGA QKVGGAQGQD ADAQDSENAG AFSQDFTEME EENKADQDPE APASPQGSQE TCPENGIYSS ALF
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
基因功能參考文獻(xiàn)：
1. HOXB4 binds to the Hemgn promoter region ex vivo & in vivo. Overexpressed Hemgn in bone marrow cells promoted cellular expansion in liquid cultures & increased self-renewal of myeloid colony-forming units. PMID: 20393131
2. Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis PMID: 14648837
3. EDAG is a key transcriptional regulator in maintaining the homeostasis of hematopoietic lineage commitment PMID: 17690693
亞細(xì)胞定位：

Nucleus.
組織特異性：

Expressed in hematopoietic precursor cells. Highly expressed in bone marrow, the red pulp of the spleen and round spermatids. Weakly expressed in peripheral blood cells.
數(shù)據(jù)庫鏈接：

KEGG: mmu:93966

STRING: 10090.ENSMUSP00000066383

UniGene: Mm.25793