Recombinant Mouse Fibromodulin (Fmod)

中文名稱：

小鼠Fmod重組蛋白
貨號：

CSB-YP008755MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Fmod重組蛋白
貨號：

CSB-EP008755MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Fmod重組蛋白
貨號：

CSB-EP008755MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Fmod重組蛋白
貨號：

CSB-BP008755MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Fmod重組蛋白
貨號：

CSB-MP008755MO
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Fmod
Uniprot No.：

P50608
別名：

FmodFibromodulin; FM; Collagen-binding 59 kDa protein; Keratan sulfate proteoglycan fibromodulin; KSPG fibromodulin
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

19-376
氨基酸序列

QY DEDSHWWIQY LRNQQSTYYD PYDPYPYEPS EPYPYGVEEG PAYAYGAPPP PEPRDCPQEC DCPPNFPTAM YCDNRNLKYL PFVPSRMKYV YFQNNQISAI QEGVFDNATG LLWVALHGNQ ITSDKVGRKV FSKLRHLERL YLDHNNLTRM PGPLPRSLRE LHLDHNQISR VPNNALEGLE NLTALYLHHN EIQEVGSSMR GLRSLILLDL SYNHLRRVPD GLPSALEQLY LEHNNVYTVP DSYFRGSPKL LYVRLSHNSL TNNGLATNTF NSSSLLELDL SYNQLQKIPP VNTNLENLYL QGNRINEFSI SSFCTVVDVM NFSKLQVLRL DGNEIKRSAM PVDAPLCLRL ANLIEI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
基因功能參考文獻：
1. Studies in knockout, obese, and diabetic mouse models helped characterize the operation of a novel FMOD-based regulatory circuit that controls myoblast switching from a myogenic to a lipid accumulation fate. FMOD regulation of myoblasts is an essential part of the myogenic program, and it offers opportunities for the development of therapeutics for the treatment of different muscle diseases PMID: 28974563
2. impact of FMOD deficiency on the development of experimental skin fibrosis is limited PMID: 26997256
3. Fibromodulin can be a unique effector of dense collagen matrix assembly in tumor stroma and, without affecting other major matrix components or the cellular composition, can function as a main agent in tumor barrier function PMID: 28827814
4. The data suggest a fibromodulin-modulated collagen cross-linking mechanism where fibromodulin binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites. PMID: 26893379
5. Suggest a more complex role for collagen in plaque stability than previously anticipated in fibromodulin-deficient/ApoE-null atherosclerotic mice. PMID: 23202368
6. The expression of decreased in the medial, basolateral, and central amygdala regions after chronic immobilization stress in mice. PMID: 22672618
7. Hepatic fibromodulin activates hepatic stellate cells and promotes collagen I deposition, which leads to liver fibrosis. PMID: 22138190
8. The differential effects of Fmod deficiency on bones and teeth appear to diverge in adult mice. PMID: 21597266
9. Fibromodulin suppresses nuclear factor-kappaB activity by inducing the delayed degradation of IKBA via a JNK-dependent pathway coupled to fibroblast apoptosis. PMID: 21156791
10. FMOD presence is critical for proper temporospatial coordination of wound healing events and normal TGF-beta bioactivity. PMID: 21191417
11. fibromodulin plays important roles in the regulation of region-specific fibrillogenesis required for the integration of the corneal and scleral matrices and sulcus development required for establishment of the visual axis PMID: 20108350
12. deficiency combined with lumican deficiency manifest several clinical features or Ehlers-Danlos syndrome PMID: 12089156
13. promote formation of a dense stroma and elevated intersitial fluid pressure, thus modulated fluid balance in thyroid cancer. PMID: 17715296
14. Dual functions may be related to the different forms of Fmod found in bone versus teeth. PMID: 18698127
15. Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding. PMID: 19008226
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily
組織特異性：

Highest levels observed in knee epiphysis, in calvarial and diaphyseal bone, in nasal and costal cartilage, in the eye, and in bladder. In mature knee joint it is mostly present in the proliferating zone of growth plate. It is also observed in ligaments,
數據庫鏈接：

KEGG: mmu:14264

STRING: 10090.ENSMUSP00000035489

UniGene: Mm.287146