Recombinant Mouse Bone morphogenetic protein receptor type-2(Bmpr2),partial
貨號:
CSB-YP002752MO
規格:
來源:
Yeast
其他:
在線留言
中文名稱:
Recombinant Mouse Bone morphogenetic protein receptor type-2(Bmpr2),partial
貨號:
CSB-EP002752MO
規格:
來源:
E.coli
其他:
在線留言
中文名稱:
Recombinant Mouse Bone morphogenetic protein receptor type-2(Bmpr2),partial
貨號:
CSB-EP002752MO-B
規格:
來源:
E.coli
共軛:
Avi-tag Biotinylated
E. coli biotin ligase
(BirA) is highly specific in covalently attaching biotin to the 15
amino
acid AviTag peptide. This recombinant protein was biotinylated in
vivo
by AviTag-BirA technology, which method is BriA catalyzes amide
linkage
between the biotin and the specific lysine of the AviTag.
其他:
在線留言
中文名稱:
Recombinant Mouse Bone morphogenetic protein receptor type-2(Bmpr2),partial
貨號:
CSB-BP002752MO
規格:
來源:
Baculovirus
其他:
在線留言
中文名稱:
Recombinant Mouse Bone morphogenetic protein receptor type-2(Bmpr2),partial
Bmpr2Bone morphogenetic protein receptor type-2; BMP type-2 receptor; BMPR-2; EC 2.7.11.30; BRK-3; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
The tag type will
be
determined during production process. If you have specified tag
type, please tell us and we will develop the specified tag
preferentially.
產品提供形式:
Lyophilized powder
Note: We will
preferentially ship the format that we have in stock, however,
if you have any special requirement for the format, please
remark your requirement when placing the order, we will prepare
according to your demand.
復溶:
We recommend that this vial be briefly centrifuged
prior
to opening to bring the contents to the bottom. Please reconstitute
protein in deionized sterile water to a concentration of 0.1-1.0
mg/mL.We recommend to add 5-50% of glycerol (final concentration)
and
aliquot for long-term storage at -20℃/-80℃. Our default final
concentration of glycerol is 50%. Customers could use it as
reference.
儲存條件:
Store at -20°C/-80°C upon receipt, aliquoting is
necessary for
mutiple use. Avoid repeated freeze-thaw cycles.
保質期:
The shelf life is related to many factors, storage
state,
buffer ingredients, storage temperature and the stability of the
protein
itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C.
The
shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期:
Delivery time may
differ from different purchasing way or location, please kindly
consult your local distributors for specific delivery time.
Note: All of our
proteins are default shipped with normal blue ice packs, if you
request to ship with dry ice, please communicate with us in
advance
and extra fees will be charged.
注意事項:
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet :
Please contact us to get it.
產品評價
靶點詳情
功能:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
基因功能參考文獻:
High BMPR2 expression is associated with aberrant synaptic development in mouse and Drosophila models of Fragile X syndrome. PMID: 28465421
BMPR2 deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6-driven prostate cancer progression PMID: 29352019
Dual luciferase report assay verified that miR-3065-5p could bind to the 3'UTR of bone morphogenetic protein receptor type II (BMPR2), which dramatically increased in the beginning of odontoblastic differentiation but decreased in the terminal differentiation stage. PMID: 29127007
increased BMPR2 signal transduction is linked to fragile X syndrome (FXS) and that the BMPR2-LIMK1 pathway is a putative therapeutic target in patients with FXS and possibly other forms of autism PMID: 27273096
Disrupting BMPR2 impairs TGFbeta1- and BMP4-mediated elastic fiber assembly and is of pathophysiologic significance in pulmonary arterial hypertension. PMID: 28619995
These results suggested that endogenous PTH enhanced BMPR2 expression by a cAMP/PKA/CREB pathway in osteoblasts, and increased RUNX2 expression through transduction of the BMP/pSMAD1/5/8 signaling pathway PMID: 28578352
Cav-1 depletion, oxidative stress-mediated reduction in BMPRII expression, and enhanced TGF-beta-driven SMAD-2/3 signaling promote pulmonary vascular remodeling in inflamed lungs. PMID: 28188225
BMPR2 gene transfer reduced TGF-beta effects on Smad2, Smad1/5/8 and Erk1/2 phosphorylation in human pulmonary arterial smooth muscle cells PMID: 26689975
loss in hippocampus and forebrain impacts exploratory and anxiety-related behaviors PMID: 26444546
Deleting Bmpr2 in mouse skeletal progenitor cells impaired activin signaling resulting in an increased bone formation rate and high bone mass. PMID: 25663702
The findings suggest that the mutant ALK2 related to Fibrodysplasia ossificans progressiva is enhanced by bone morphogenetic protein type II receptors via the T203-regulated phosphorylation of ALK2. PMID: 25354296
BMPR2 has tumor suppressive functions in the stroma by regulating inflammation. PMID: 25205038
Serotonin can increase ERalpha expression in human pulmonary arterial smooth muscle cells and antagonism of oestrogen receptor alpha reverses serotonin-dependent PH in the mouse and increases bone morphogenetic protein receptor type 2 expression PMID: 25765937
BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. PMID: 25863249
Members of the miR-17 family influence gastrulation by suppressing Bmpr2 expression at the primitive streak. PMID: 25209090
Mutations in BMPR2 underlie most heritable cases and a small proportion of sporadic cases of idiopathic pulmonary arterial hypertension. PMID: 26030479
BMP9 is identified as the preferred ligand for preventing apoptosis and enhancing monolayer integrity in endothelial cells from subjects with pulmonary arterial hypertension who bear mutations in the gene encoding BMPR2. PMID: 26076038
These data suggest that heterozygous null BMPR2 mutations promote SRC-dependent caveolar trafficking defects in PECs and that this may contribute to pulmonary endothelial barrier dysfunction in Hereditary pulmonary arterial hypertension patients PMID: 25411245
BMPR2 expression potentiated activin A responses whereas depletion of endogenous BMPR2 with short interfering RNAs attenuated activin A-stimulated follicle-stimulating hormone beta transcription in gonadotrope-like cells. PMID: 24018044
BMP type II receptors, BMPR2 and ActR2a, have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism. PMID: 25075125
Data indicate that mice with heterozygous mutant bone morphogenetic protein (BMP) type II receptor (BMPR2) grew normally without developing pulmonary arterial hypertension. PMID: 24116187
data indicate that the endogenous NMD negative BMPRDeltaEx2 mutant product is expressed but has a folding defect resulting in ER retention. PMID: 24224048
reduced BMPR2 can subvert a stress granule response, heighten GM-CSF mRNA translation, increase inflammatory cell recruitment, and exacerbate pulmonary arterial hypertension PMID: 24446489
Impaired right ventricle (RV) hypertrophy was associated with triglyceride deposition in mice with mutant Bmpr2 expression in RV. Human RVs with heritable pulmonary arterial hypertension showed lipid deposition and alteration in fatty acid oxidation. PMID: 24274756
Hyperoxia synergizes with Bmpr2 mutations to cause metabolic stress, oxidant injury, and pulmonary hypertension. PMID: 23742019
In mice with conditional endothelial cell Bmpr2 deletion, low-dose FK506 prevented exaggerated chronic hypoxic pulmonary hypertension. PMID: 23867624
Abnormalities in uterine BMPR2-mediated signaling pathways can have catastrophic consequences in women for the maintenance of pregnancy. PMID: 23676498
Bmpr2 and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division. PMID: 22611050
BMPR-II dysfunction promotes the activation of small mothers against decapentaplegia-independent mitogen-activated protein kinase pathways via TGFbeta-associated kinase 1, resulting in a pro-proliferative and anti-apoptotic response PMID: 22388934
BMPR-II is not required for endochondral ossification in the limb where loss of BMPR-II may be compensated by BMP utilization of Acvr2a and Acvr2b. PMID: 21538804
Functional redundancy in osteoblast differentiation is observed between bone morphogenetic protein receptor BMPR-II and activin receptor ActR-IIB. PMID: 21503889
The expression of Bmpr2 in the proximal outflow tract septum was delayed in CX43 knockout mice. PMID: 22094042
cytoskeletal defects are common to multiple BMPR2 mutations and are associated with activation of the Rho GTPase, Rac1 PMID: 22180660
BMPR2 has tumor-suppressive function in mammary epithelia and microenvironment and that disruption can accelerate mammary carcinoma metastases. PMID: 21576484
CXCR1/2 pathway antagonists may represent a novel therapeutic approach for treating pulmonary hypertension because of defects in BMPR-II expression. PMID: 21900197
Bmpr2 mutation in endothelial cells may drive pulmonary arterial hypertension through multiple, potentially independent, downstream mechanisms, including proliferation, apoptosis, inflammation, and thrombosis. PMID: 21696628
Data describe a BMPR2-mediated transcriptional complex between PPARgamma and beta-catenin, and suggest that apelin could be effective in treating PAH by rescuing BMPR2 and PAEC dysfunction. PMID: 21821917
findings confirm ET-1 and its receptors are present in lung macrophages; ETA and ETB receptor expression is decreased in bone marrow-derived macrophages from a BMPR2 mutant mouse model of heritable pulmonary artery hypertension compared with controls PMID: 20562228
An in vivo tool to study the role of BMPRII in BMP/Smad signaling and the regulation of this pathway by PTH and Wnts. PMID: 20392248
Bone morphogenetic protein 7 rapidly activates c-Jun N-terminal kinases (JNKs), and JNKs associate with the carboxy terminus of the BMP receptor, BMPRII. PMID: 20176805
Loss of BMPRII signaling in smooth muscle is sufficient to produce the pulmonary hypertensive phenotype. PMID: 15031260
Mutation of one copy of the BMPR-II gene causes pulmonary hypertension but impairs the ability of the pulmonary vasculature to remodel in response to prolonged hypoxic breathing. PMID: 15286002
Results define a pathway linking the bone morphogenetic protein receptor BMPRII to regulation of actin and provides insights into how extracellular signals modulate LIMK1 activity during dendritogenesis. PMID: 15538389
loss of Bmpr2 leads to the net gain of signaling by some, but not all, BMP ligands via the activation of ActRIIa PMID: 15883158
Our data suggest that the complex formation between c-kit and BMPR-II leads to phosphorylation of BMPR-II at Ser757, which modulates BMPR-II-dependent signaling PMID: 16155937
BMP pathway regulates IL-6 in pulmonary tissues and conversely that IL-6 regulates the BMP pathway PMID: 17322283
relevance of BMPR2 dysregulation may extend beyond proliferation in idiopathic pulmonary artery hypertension PMID: 17369292
identified the receptor for activated C-kinase (RACK1) as a novel interaction partner of BMPRII by yeast 2-hybrid analyses using the kinase domain of BMPRII as a bait. PMID: 17515463
Inactivation in the stroma leads to epithelial hyperplasia throughout the colon with increased epithelial cell proliferation; mutant mice develop rectal bleeding and hamartomatous polyps in the colorectum. PMID: 17700526
Pulmonary endothelium is a target of abnormal Bmpr2 mutant mice, suggesting that endothelial dysfunction contributes to increased susceptibility to hypoxic pulmonary hypertension. PMID: 18024717
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亞細胞定位:
Cell membrane; Single-pass type I membrane protein.
蛋白家族:
Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily