Recombinant Human Rho GTPase-activating protein 8 (ARHGAP8)

中文名稱：

Recombinant Human Rho GTPase-activating protein 8(ARHGAP8)
貨號：

CSB-YP002035HU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Rho GTPase-activating protein 8(ARHGAP8)
貨號：

CSB-EP002035HU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Rho GTPase-activating protein 8(ARHGAP8)
貨號：

CSB-EP002035HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Rho GTPase-activating protein 8(ARHGAP8)
貨號：

CSB-BP002035HU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Rho GTPase-activating protein 8(ARHGAP8)
貨號：

CSB-MP002035HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ARHGAP8
Uniprot No.：

P85298
別名：

ARHGAP8; Rho GTPase-activating protein 8; Rho-type GTPase-activating protein 8
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-464
氨基酸序列

MAGQDPALST SHPFYDVARH GILQVAGDDR FGRRVVTFSC CRMPPSHELD HQRLLEYLKY TLDQYVENDY TIVYFHYGLN SRNKPSLGWL QSAYKEFDRK DGDLTMWPRL VSNSKLKRSS HLSLPKYWDY RYKKNLKALY VVHPTSFIKV LWNILKPLIS HKFGKKVIYF NYLSELHEHL KYDQLVIPPE VLRYDEKLQS LHEGRTPPPT KTPPPRPPLP TQQFGVSLQY LKDKNQGELI PPVLRFTVTY LREKGLRTEG LFRRSASVQT VREIQRLYNQ GKPVNFDDYG DIHIPAVILK TFLRELPQPL LTFQAYEQIL GITCVESSLR VTGCRQILRS LPEHNYVVLR YLMGFLHAVS RESIFNKMNS SNLACVFGLN LIWPSQGVSS LSALVPLNMF TELLIEYYEK IFSTPEAPGE HGLAPWEQGS RAAPLQEAVP RTQATGLTKP TLPPSPLMAA RRRL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
基因功能參考文獻：
1. Fusion protein PRR5-ARHGAP8 plays a role in bipolar disorder with binge eating behavior. PMID: 29391396
2. BPGAP1 provides a crucial spatiotemporal checkpoint where JNK and MP1/MEK1 work in concert to regulate endosomal and nuclear ERK signaling in cell proliferation control. PMID: 28092672
3. Pin1 regulates BPGAP1 function in Rho and Erk signalling, with active Mek2 serving as a novel regulatory scaffold that promotes crosstalk between RhoGAP, Pin1 and Erk in the regulation of cell migration. PMID: 20179103
4. BPGAP1 has a role in regulating cell dynamics with BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of BPGAP1 PMID: 12944407
5. RhoGAP functionally interacts with cortactin and represents a novel determinant in the regulation of cell dynamics. PMID: 15064355
6. ARHGAP8 expression was up-regulated in the majority of primary colorectal tumors analyzed in this work. PMID: 15225876
7. BPGAP1 is a novel RhoGAP that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 and Cdc42GAP homology domains. PMID: 15506981
8. findings reveal a concomitant activation of endocytosis and ERK signaling by BPGAP1 via the coupling of its proline-rich region, which targets EEN and its functional GAP domain PMID: 15944398
9. This paper compares the protein sequences and genomic structures of human and mouse ARHGAP8. PMID: 12559566
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組織特異性：

Highly expressed in kidney and placenta. Also expressed in colon, skeletal muscle, small intestine, stomach, and testis. Not detected in brain, liver or spleen. Overexpressed in the majority of colorectal tumors examined.
數據庫鏈接：

HGNC: 677

OMIM: 609405

KEGG: hsa:23779

STRING: 9606.ENSP00000262731

UniGene: Hs.102336