Recombinant Human Reticulon-4 receptor (RTN4R)

中文名稱：

人RTN4R重組蛋白
貨號：

CSB-YP880152HU
規格：
來源：

Yeast
其他：

中文名稱：

人RTN4R重組蛋白
貨號：

CSB-EP880152HU
規格：
來源：

E.coli
其他：

中文名稱：

人RTN4R重組蛋白
貨號：

CSB-EP880152HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RTN4R重組蛋白
貨號：

CSB-BP880152HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人RTN4R重組蛋白
貨號：

CSB-MP880152HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RTN4R
Uniprot No.：

Q9BZR6
別名：

RTN4R; NOGOR; UNQ330/PRO526Reticulon-4 receptor; Nogo receptor; NgR; Nogo-66 receptor
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

27-447
氨基酸序列

CPGA CVCYNEPKVT TSCPQQGLQA VPVGIPAASQ RIFLHGNRIS HVPAASFRAC RNLTILWLHS NVLARIDAAA FTGLALLEQL DLSDNAQLRS VDPATFHGLG RLHTLHLDRC GLQELGPGLF RGLAALQYLY LQDNALQALP DDTFRDLGNL THLFLHGNRI SSVPERAFRG LHSLDRLLLH QNRVAHVHPH AFRDLGRLMT LYLFANNLSA LPTEALAPLR ALQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCSLP QRLAGRDLKR LAANDLQGCA VATGPYHPIW TGRATDEEPL GLPKCCQPDA ADKASVLEPG RPASAGNALK GRVPPGDSPP GNGSGPRHIN DSPFGTLPGS AEPPLTAVRP EGSEPPGFPT SGPRRRPGCS RKNRTRSHCR LGQAGSGGGG TGDSEGS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development.
基因功能參考文獻：
1. Results indicate an association between RTN4R genetic variation and phenotypes linked to prefrontal function. In an hierarchical approach, a SNP (rs696884) selected based on its association with RTN4R postmortem mRNA expression in the prefrontal cortex was shown to modulate prefrontal activity during working memory processing. PMID: 28755979
2. NgR1 ligand has a role in in oligodendrocyte progenitor cells fate in the context of a specific and common type of stroke PMID: 27956620
3. Allelic variation of the rs701428 SNP of RTN4R was significantly associated with volumetric differences in gray matter of the lingual gyrus and cuneus of the occipital lobe. Moreover, occipital gray matter volumes were robustly associated with ultra high risk symptoms of psychosis in the presence of the G allele of rs701428. PMID: 28139055
4. Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1, RhoA, and ROCK2. PMID: 27288754
5. (188)Re-NGR-VEGI has the potential as a theranostic agent. PMID: 26768609
6. Messenger RNA expression from RTN4R in human cortical brain tissue correlated significantly with the genotypes of rs701427. Observations suggest that a functional RTN4R gene variant is associated with sporadic ALS. PMID: 26083872
7. Authors highlight the structural and biochemical aspects of the interaction of Nogo receptors (R1 and R2) with myelin inhibitors such as MAG, Nogo A and OMgp.[Review] PMID: 24956133
8. NgR1 is a neural entry mediator for mammalian reovirus.NgR1 is required for efficient infection of primary cortical neurons by reovirus. PMID: 24922571
9. Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1) is intracellular and competes with Nogo-66 receptor (NgR) for binding to p75 neurotrophin receptor (p75NTR). PMID: 25666623
10. This study demonistrated that alterations in DTI metrics suggest white matter microstructural anomalies of the cerebral cortex in 22q11.2DS. Structural differences in ALIC appear to be associated with the Nogo-66 receptor gene. PMID: 24321711
11. Strong overexpression of Nogo receptor 1 in forebrain neurons impairs aspects of cognitive function but does not alter plaque load in plaque-forming transgenic animals. PMID: 22903127
12. After optic nerve crush injury, transgenic NgR1-deficient neurons regenerate retinal ganglion axons as extensively as do zymosan-injected, macrophage-activated wild-type mice. PMID: 22728374
13. Expression of Nogo-66 receptor in human astrocytoma is correlated with tumor malignancy. PMID: 21681431
14. These results indicate that a lack of NgR1/2 expression promotes the adhesion of DCs to myelin. PMID: 21906273
15. The results of this study suggested that Lack of association of the RTN4R genetic variations with risk of schizophrenia and SPEM abnormality in a Korean population. PMID: 21377214
16. Kiaa0319-like protein interacts with Nogo Receptor 1, supporting the idea that Kiaa0319-like protein participates in axon guidance. PMID: 20697954
17. In acute slices of adult mice, transgenic NGR suppresses long-term potentiation when locally applied to hippocampal CA1 synapses. PMID: 20844138
18. Hypermethylation of NOGOR gene is associated with adenocarcinoma. PMID: 20524398
19. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth PMID: 12068310
20. Nogo-66-R mRNA expression in humans and mice was observed in neurons of the developing nervous system; expression was downregulated in the adult spinal cord of both species, and specific expression patterns were seen in the adult brain. PMID: 12378589
21. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG (myelin-associated glycoprotein) and OMgp PMID: 12422217
22. Nogo-66 receptor (NgR) proteolysis occurs within the human nervous system indicating a potential cellular mechanism for the regulation of NgR function at the level of the receptor PMID: 15331667
23. the role of the RTN4R as a candidate gene for schizophrenia PMID: 15532024
24. Expression of the genes encoding Nogo and its receptor, NgR, between weeks eight and 23 of human embryonic development. PMID: 15749087
25. analysis revealed a novel disulfide structure in the C-terminal region (CT) of the NgR1, wherein the two Cys residues, Cys-335 and Cys-336, in the CT stalk are disulfide-linked to Cys-266 and Cys-309 in the LRRCT region PMID: 16342940
26. results suggest that there is no significant association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Han Chinese population PMID: 16897606
27. The molecular requirements for cerebral amyloid-beta peptide interaction with NgR are defined and correlated with the affinity of these polypeptides to improve spatial memory impairments in Alzheimer disease model mice. PMID: 17182778
28. results showed that NgR immunoreactivity was present in more than 50% of the pyramidal layer cells of the CA1 to CA4 subfields of the hippocampus; results suggest that NgR may be related to the formation of tangles in Alzheimer's disease PMID: 17188332
29. Review highlights the function of Nogo-66 receptor-1 (NgR-1) during myelin inhibition. PMID: 17959786
30. RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes PMID: 18043741
31. For a restricted subset of individuals diagnosed with schizophrenia, the expression of dysfunctional NGR variants may contribute to increased disease risk. PMID: 19052207
32. We conclude that NgR1 alters the motility of immune cells exposed to myelin and may thus impact their behaviour within the CNS, particularly under conditions when immune cell activation is heightened. PMID: 19328785
33. This review summarizes recent research that generates interest in the Nogo-66 receptor (NgR1) as a focus of study in central nervous system injury and for its function in increasing susceptibility to developing schizophrenia. PMID: 19386899
34. Nogo-66 receptor (NgR)is identified as a high affinity receptor for BLyS; BLyS can function independently of myelin-associated inhibitors & likely serves as a redundant NgR ligand that negatively influences axonal outgrowth in the central nervous system PMID: 19439611
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相關疾病：

Schizophrenia (SCZD)
亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Cell projection, axon. Perikaryon.
蛋白家族：

Nogo receptor family
組織特異性：

Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter).
數據庫鏈接：

HGNC: 18601

OMIM: 181500

KEGG: hsa:65078

STRING: 9606.ENSP00000043402

UniGene: Hs.30868