Recombinant Human Regulator of G-protein signaling 2 (RGS2)

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中文名稱：

人RGS2重組蛋白
品名簡稱：

Recombinant Human RGS2 protein
貨號：

CSB-EP019651HU
說明書：

MSDS Datasheet
規(guī)格：

￥1344
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

RGS2
Uniprot No.：

P41220
別名：

Basic helix-loop-helix phosphoprotein G0S8; Cell growth inhibiting protein 31; Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8 24kD; G0/G1 switch regulatory protein 8; G0S8; GOS8; OTTHUMP00000060765; Regulator of G protein signaling 2; Regulator of G protein signalling 2 24kD; Regulator of G-protein signaling 2; Regulators of G protein signaling XRGSVI; RGS 2; RGS2; RGS2_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

E.coli
分子量：

40.4kDa
表達區(qū)域：

1-211aa
氨基酸序列

MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-SUMO-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
基因功能參考文獻：
1. Results showed no association between genotypes and preeclampsia for polymorphisms rs5186, rs4606 in 3'UTR of genes ACVR2A, AGTR1 and RGS2 in women with preeclampsia PMID: 29593124
2. RGS2 is suggested as a novel AD biomarker (alongside other genes) toward early AD detection and future disease modifying therapeutics. PMID: 27701409
3. Upregulated RGS2 contributes significantly to the anti-fibrotic effects of pirfenidone in idiopathic pulmonary fibrosis. PMID: 27549302
4. study provides functional data for 16 human RGS2 missense variants on their effects on AT1R-mediated calcium mobilization and provides molecular understanding of those variants with functional loss in vitro. PMID: 28784619
5. Our results suggest that RGS2 might be involved in the pathogenesis of preeclampsia particularly in overweight women and contribute to their increased risk for hypertension and other types of cardiovascular disease later in life. PMID: 27558088
6. Data suggest that epigenetic changes in histone acetylation and DNA methylation may contribute to the repression of RGS2 (regulator of G-protein signaling 2) expression in chemo-resistant ovarian cancer cells; regulation of HDAC1 (histone deacetylase 1) and DNMT1 (DNA methyltransferase 1) contribute to the suppression of RGS2. PMID: 28102109
7. The RGS2 (-391, C>G) genetic polymorphism may serve as a biomarker to predict a patient's response to antihypertensive drug therapy PMID: 25849301
8. MIR4717 regulates human RGS2 and contributes to the genetic risk towards anxiety-related traits. PMID: 25847876
9. FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex. PMID: 25970626
10. RGS2 polymorphisms were found to be associated with anxiety disorders and dimensional as well as intermediate phenotypes of anxiety. PMID: 25740197
11. RGS2 localizes to the mitotic spindle in a Nek7-dependent manner, and along with Nek7 contributes to spindle morphology and mitotic spindle pole integrity. PMID: 25664600
12. genetic variations and increased inflammatory cytokines can lead to RGS2 repression, which exacerbates AHR and airway remodeling in asthma. PMID: 25368964
13. Data show that regulator of G protein signaling 2 (RGS2) was stabilized by deubiquitinase monocyte chemotactic protein-induced protein 1 (MCPIP1). PMID: 25187114
14. Epigenetic repression of RGS2 by UHRF1 contributes to bladder cancer progression. UHRF1 inhibits RGS2 expression by increasing the methylation of CpG nucleotides of the RGS2 promoter. PMID: 25323766
15. ACE and RGS2 genotypes are not associated with the development of hypertension in patients with type 1 diabetes mellitus. PMID: 24562335
16. This work highlights the role of RGS2 as a key regulator of LRRK2 activity, function and neuronal toxicity. PMID: 24794857
17. study found that wild-type Met-Gln-Rgs2 and its mutant, Met-Arg-Rgs2, were destroyed by the Ac/N-end rule pathway, which recognizes N(alpha)-terminally acetylated (Nt-acetylated) proteins PMID: 25766235
18. The results of this study are consistent previous results and support the hypothesis that polymorphic loci RGS2 gene associated with risk of extrapyramidal symptoms induced by typicalneuroleptics-haloperidol, and are involved in schizophrenia pathway. PMID: 25509855
19. Women carrying the rs4606 CG or GG genotype are at elevated risk for developing hypertension after delivery following a preeclamptic pregnancy. PMID: 24593135
20. This meta-analysis revealed that the RGS2 1891-1892del TC polymorphism and CYP4A11 T8590C polymorphism were associated with hypertension risk. PMID: 23859711
21. observations support the concept of a functional activation-dependent p63RhoGEF-Galphaq-RGS2 complex PMID: 24299002
22. ectopic expression of R4 subfamily members RGS2, RGS3, RGS4, and RGS5 reduced activated PAR1 wild-type signaling, whereas signaling by the PAR1 AKKAA mutant was minimally affected. PMID: 24297163
23. RGS2 promoter of hypertensive patients abolished HSF1-regulated expression of RGS2, suggesting that activated HSF1 is involved in blood pressure regulation via modulation of RGS2 expression PMID: 23587726
24. The study was unable to replicate or extend prior association findings between RGS2 variants and various anxiety-related phenotypes using a large, independent sample. PMID: 23277133
25. Data show that miR-22 specifically interacts with the 3' UTRs of the Rcor1, Rgs2 and HDAC4 mRNAs. PMID: 23349832
26. It was shown that the RGS2 rs4606 single nucleotide polymorphism may affect the risk and progression of preeclampsia. PMID: 23339167
27. The variants and their frequencies in RGS2 gene in Kazakh hypertensives may have ethnic differences when compared with other populations. PMID: 21529451
28. In vivo treatment with digoxin led to increased RGS2 protein levels in heart and kidney. PMID: 22695717
29. Loss of RGS2 also increased ASM mass and stimulated airway smooth muscle cell growth via extracellular signal-regulated kinase and phosphatidylinositol 3-kinase pathways PMID: 22704538
30. Reduced RGS2 protein expression in human prostate cancer specimens. PMID: 21500190
31. Data identify RGS2 gene expression as a genomic mechanism of bronchoprotection that is induced by glucocorticoids plus beta(2)-adrenoceptor agonist (LABA) in airway smooth muscle. PMID: 22080612
32. Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 PMID: 22057271
33. Findings both identify RGS2 downregulation as a novel compensatory response in HD neurons and suggest that RGS2 inhibition might be considered as an innovative target for neuroprotective drug development. PMID: 21779398
34. genetic polymorphisms in RGS2 are associated with intima-media thickening of carotid artery in humans. PMID: 21451528
35. The haplotypes T-G-C and T-C-T showed significant association and protective effect on Panic disorder; results provide support for an association of RGS2 with panic disorder in a Japanese population PMID: 21438143
36. The essential roles of both N-terminal subdomains for the potent inhibitory activity of RGS2 on AT1 receptor signaling. PMID: 21291998
37. down-regulation of RGS2 might play an important role in colorectal cancer (CRC) metastasis and predict poor prognosis in stage II and III CRC patients. PMID: 20001967
38. These findings suggest that RGS2 may not be genetically involved in the biological susceptibility to panic disorder in Japanese. PMID: 20847599
39. platelet Gs signaling defect caused by a heterozygous RGS2 variant that results in a unique mutational mechanism, such as the differential use of translation initiation sites resulting in different functional RGS2 isoforms. PMID: 20403096
40. The D allele of 1891-1892 TC insertion/deletion of RGS2 might be an independent risk factor for hypertension in Xinjiang Kazakhs. PMID: 20662725
41. data suggest that RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms in vivo PMID: 20633139
42. Reduced RGS2 expression contributes to resistance to antihypertensive agents through poor negative feedback on the effects of aldosterone and of other vasoactive agents. PMID: 20375904
43. The D allele of the 1891-1892TC insertion/deletion locus of the RGS2 gene is an independent risk factor for hypertension in a Chinese population. PMID: 20140863
44. Ischemic stress increases RGS2 expression and that this condition contributes to enhanced apoptosis in C6 cells and primary astrocytes. PMID: 20032508
45. Phosphoglycerate kinase 2 (PGK2) showed a difference between follicular cells from follicles leading to a pregnancy or developmental failure. PMID: 19778949
46. rs4606 does not affect AIEPSs in Japanese subjects. PMID: 19931593
47. RGS2 plays a role in regulating purinergic signaling in human broncheotracheal cells PMID: 12356577
48. Identification of RGS2 and type V adenylyl cyclase interaction sites. PMID: 12604604
49. RGS-2 level in human clinical condition characterized by altered vascular tone. Importance of RGS-2 as key regulator element for Ang II signaling. Links between Bartter's/Gitelman's syndrome genetic abnormalities and abnormal vascular tone regulation. PMID: 15292363
50. TSH-dependent RGS 2 mRNA expression and the suppression of TSH-G(q)alpha signaling by the overexpression of RGS 2 imply that RGS 2 is involved in TSHR-induced G(q) signal transduction. PMID: 15362969
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亞細胞定位：

[Isoform 1]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 2]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 3]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 4]: Cell membrane. Mitochondrion.
組織特異性：

Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
數(shù)據(jù)庫鏈接：

HGNC: 9998

OMIM: 600861

KEGG: hsa:5997

STRING: 9606.ENSP00000235382

UniGene: Hs.78944