Recombinant Human Rab effector MyRIP (MYRIP), partial

中文名稱(chēng)：

人MYRIP重組蛋白
貨號(hào)：

CSB-YP839876HU
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

人MYRIP重組蛋白
貨號(hào)：

CSB-EP839876HU
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

人MYRIP重組蛋白
貨號(hào)：

CSB-EP839876HU-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

人MYRIP重組蛋白
貨號(hào)：

CSB-BP839876HU
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

人MYRIP重組蛋白
貨號(hào)：

CSB-MP839876HU
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

MYRIP
Uniprot No.：

Q8NFW9
別名：

DKFZp586F1018; Exophilin 8; Exophilin; Exophilin-8; Exophilin8; FLJ44025; MGC130034; MGC130035; Myosin VIIA and Rab interacting protein; Myosin-VIIa- and Rab-interacting protein; Myrip; MYRIP_HUMAN; Rab effector MyRIP; SLAC 2C; SLAC2 C; SlaC2-c; SLAC2C; Slp homolog lacking C2 domains c; Slp homologue lacking C2 domains; Slp homologue lacking C2 domains c; Synaptotagmin like protein homologue lacking C2 domains c; synaptotagmin-like protein lacking C2 domains C
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release.
基因功能參考文獻(xiàn)：
1. The role of MyRIP in Ca(2+)-driven exocytosis requires both MyoVa- and actin-binding potential. PMID: 26675235
2. Myrip couples the retention of secretory granules in the cell cortex, their transport to the plasma membrane, and their attachment to the plasma membrane, thus promoting secretion. PMID: 22396429
3. A Rab27a/MyRIP/myosin Va complex is involved in linking von-Willebrand factor (Vwf) to the peripheral actin cytoskeleton of endothelial cells to allow full maturation and prevent premature secretion of vWF. PMID: 21740491
4. A new potentially protective effect was identified at rs2679798 in MYRIP. PMID: 20861866
5. a molecular complex composed of Rab27A, MyRIP and myosin VIIa bridges retinal melanosomes to the actin cytoskeleton and thereby mediates the local trafficking of these organelles PMID: 11964381
6. Slac2c/MyRIP is part of a complex mediating the interaction of secretory granules with cortical actin cytoskeleton PMID: 14517322
7. During primate spermiogenesis, dynein, myosin Va, MyRIP and Rab27b that compose microtubule-based and actin-based vesicle transport systems are actually present in the manchette and might possibly be involved in intramanchette transport. PMID: 18478159
8. Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. PMID: 19270261
9. Slac2-c/MyRIP contains an N-terminal Slp homology domain (SHD) and functions as a linker protein that interacts with myosin Rab27A/B, VIIa/Va, and actin. PMID: 12221080
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亞細(xì)胞定位：

Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle.
組織特異性：

Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 19156

OMIM: 611790

KEGG: hsa:25924

STRING: 9606.ENSP00000301972

UniGene: Hs.594535