Recombinant Human RING finger protein 170 (RNF170), partial

中文名稱：

人RNF170重組蛋白
貨號：

CSB-YP019857HU1
規格：
來源：

Yeast
其他：

中文名稱：

人RNF170重組蛋白
貨號：

CSB-EP019857HU1
規格：
來源：

E.coli
其他：

中文名稱：

人RNF170重組蛋白
貨號：

CSB-EP019857HU1-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RNF170重組蛋白
貨號：

CSB-BP019857HU1
規格：
來源：

Baculovirus
其他：

中文名稱：

人RNF170重組蛋白
貨號：

CSB-MP019857HU1
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RNF170
Uniprot No.：

Q96K19
別名：

RNF170; E3 ubiquitin-protein ligase RNF170; Putative LAG1-interacting protein; RING finger protein 170; RING-type E3 ubiquitin transferase RNF170
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.
基因功能參考文獻：
1. aberrant ubiquitination of substrates, or cellular adaptation to chronically reduced RNF170 levels likely accounts for the autosomal dominant sensory ataxia-associated Ca2+ signaling deficit PMID: 25882839
2. RNF170 plays an essential role in IP(3) receptor processing via the ubiquitin-proteasome pathway. PMID: 21610068
3. Together these results suggest that the mutation in RNF170 is causal for the sensory ataxia PMID: 21115467
相關疾病：

Ataxia, sensory, 1, autosomal dominant (SNAX1)
亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
組織特異性：

Expressed in the spinal chord.
數據庫鏈接：

HGNC: 25358

OMIM: 608984

KEGG: hsa:81790

STRING: 9606.ENSP00000434797

UniGene: Hs.491626