Recombinant Human Protocadherin Fat 4 (FAT4), partial

中文名稱：

人FAT4重組蛋白
貨號：

CSB-YP740927HU
規格：
來源：

Yeast
其他：

中文名稱：

人FAT4重組蛋白
貨號：

CSB-EP740927HU
規格：
來源：

E.coli
其他：

中文名稱：

人FAT4重組蛋白
貨號：

CSB-EP740927HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人FAT4重組蛋白
貨號：

CSB-BP740927HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人FAT4重組蛋白
貨號：

CSB-MP740927HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

FAT4
Uniprot No.：

Q6V0I7
別名：

Cadherin family member 14; Cadherin related family member 11; CDHF14; CDHR11; FAT atypical cadherin 4; FAT J; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; FAT4; FAT4_HUMAN; FATJ; hFat4; HKLLS2; Nbla00548; Protocadherin Fat 4; Putative protein product of Nbla00548; VMLDS2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation.
基因功能參考文獻：
1. The results provide direct evidence that localized feedbacks on Fat4-Ds1 complexes can give rise to planar cell polarity. PMID: 28826487
2. Study shows that when key regulators during mammalian cerebral cortical development are disrupted due to DCHS1-FAT4 mutations, functional cerebral asymmetries are stronger. PMID: 25930014
3. Epigenetic inactivation of FAT4 contributes to gastric field cancerization. PMID: 26792292
4. In hepatocellular carcinoma patients, both FAT4 expression and FAT4 mutational status significantly correlated with patient prognosis. FAT4 acts as a putative tumor suppressor that is frequently inactivated in human hepatocellular carcinoma. PMID: 26672766
5. In conclusion, Fat4 expression is deceased in gastric cancer cells, leading to nuclear translocation of Yap and correlates with poor prognosis. PMID: 26575609
6. FAT4 has a tumour suppressor role mediated by the modulation of Wnt/beta-catenin signalling, providing potential novel targets for the treatment of gastric cancer PMID: 26633557
7. our results reveal a novel inhibitory mechanism of FAT4 gene expression through actin depolymerization during Src-induced carcinogenesis in human breast cells. PMID: 25679223
8. These findings suggest that Fat and Dachsous self-bend due to the loss of Ca(2+)-binding amino acids from specific EC-EC linkers, and can therefore adapt to confined spaces. PMID: 25355906
9. study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A. PMID: 24349473
10. Homozygosity mapping and whole-exome sequencing was used in the original Hennekam syndrome family with multiple affected individuals in whom no CCBE1 mutation had been detected, and identified a homozygous mutation in the FAT4 gene. PMID: 24913602
11. findings show that mutations in genes encoding the receptor-ligand cadherin pair DCHS1 and FAT4 lead to a recessive syndrome in humans that includes periventricular neuronal heterotopia PMID: 24056717
12. The atypical cadherin Fat4 encodes at least part of the stromal cell differentiation signal. PMID: 23974041
13. the nonsynonymous variants rs1014867 (Pro4972Ser) and rs1039808 (Ala807Val) of FAT4 may contribute to esophageal cancer susceptibility PMID: 23319386
14. Recurrent somatic mutations in FAT4 gene is associated with gastric adenocarcinoma. PMID: 22484628
15. Fat4 may be a breast tumor suppressor gene PMID: 19048595
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相關疾病：

Van Maldergem syndrome 2 (VMLDS2); Hennekam lymphangiectasia-lymphedema syndrome 2 (HKLLS2)
亞細胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer.
數據庫鏈接：

HGNC: 23109

OMIM: 612411

KEGG: hsa:79633

STRING: 9606.ENSP00000377862

UniGene: Hs.563205