Recombinant Human Pancreatic secretory granule membrane major glycoprotein GP2 (GP2)

中文名稱：

人GP2重組蛋白
貨號：

CSB-YP009687HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人GP2重組蛋白
貨號：

CSB-EP009687HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人GP2重組蛋白
貨號：

CSB-EP009687HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人GP2重組蛋白
貨號：

CSB-BP009687HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人GP2重組蛋白
貨號：

CSB-MP009687HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

GP2
Uniprot No.：

P55259
別名：

DKFZp779K0533; Glycoprotein 2 (zymogen granule membrane); GP2; GP2_HUMAN; Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane associated protein GP2; Pancreatic zymogen granule membrane protein GP-2; ZAP75
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

29-512
氨基酸序列

VQ RGYGNPIEAS SYGLDLDCGA PGTPEAHVCF DPCQNYTLLD EPFRSTENSA GSQGCDKNMS GWYRFVGEGG VRMSETCVQV HRCQTDAPMW LNGTHPALGD GITNHTACAH WSGNCCFWKT EVLVKACPGG YHVYRLEGTP WCNLRYCTVP RDPSTVEDKC EKACRPEEEC LALNSTWGCF CRQDLNSSDV HSLQPQLDCG PREIKVKVDK CLLGGLGLGE EVIAYLRDPN CSSILQTEER NWVSVTSPVQ ASACRNILER NQTHAIYKNT LSLVNDFIIR DTILNINFQC AYPLDMKVSL QAALQPIVSS LNVSVDGNGE FIVRMALFQD QNYTNPYEGD AVELSVESVL YVGAILEQGD TSRFNLVLRN CYATPTEDKA DLVKYFIIRN SCSNQRDSTI HVEENGQSSE SRFSVQMFMF AGHYDLVFLH CEIHLCDSLN EQCQPSCSRS QVRSEVPAID LARVLDLGPI TRRGAQSPGV MN
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participate in the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response.
基因功能參考文獻：
1. Data indicate the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ pancreatic progenitors (PPs). PMID: 28835709
2. Totals of 12.4% and 20.8% of Crohn's disease patients were positive for IgA/IgG type of anti-GP2 and anti-CUZD1, respectively. Positivity for anti-pancreatic autoantibodies predicted a faster progression towards complicated disease course. PMID: 25968583
3. Anti-GP2 antibody positive CD patients had higher ASCA titres compared to seronegative cases. PMID: 23118780
4. A novel role for GP2 in immune regulation could provide a platform for new therapeutic interventions in the treatment of Crohn disease. PMID: 22891285
5. GP2 is a binding partner of the scavenger receptor expressed on endothelial cells I (SREC-I) but not of SR-AI and SR-BI. Dendritic cells express SREC-I and also bind and internalize GP2. PMID: 21190681
6. GP2 gene is unlikely to play a major role in the etiology of chronic pancreatitis. PMID: 20335779
7. Data suggest that GP2 alterations do not alter the risk for the development of chronic pancreatitis. PMID: 19959969
8. This study represents the first detailed analysis of any variation in the GP2 gene and gives some support to the putative association of c.1275A>G with chronic pancreatitis disease protection. PMID: 19919903
9. GP2 binds to Type 1 fimbria, a bacterial adhesin that is commonly expressed by members of the Enterobacteriacae family. PMID: 19627615
10. glycoprotein 2 (GP2), specifically expressed on the apical plasma membrane of M cells among enterocytes, serves as a transcytotic receptor for mucosal antigens PMID: 19907495
11. According to human genome blasts for Build 35.1, this gene is located on 16p12 not 9q21 as described in this paper. PMID: 9605860
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亞細胞定位：

Zymogen granule membrane; Lipid-anchor, GPI-anchor. Secreted. Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane; Lipid-anchor, GPI-anchor. Membrane raft; Lipid-anchor, GPI-anchor. Endosome.
組織特異性：

Expressed in pancreas (at protein level). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level).
數據庫鏈接：

HGNC: 4441

OMIM: 602977

KEGG: hsa:2813

STRING: 9606.ENSP00000370767

UniGene: Hs.53985