Recombinant Human Mastermind-like protein 3 (MAML3), partial

中文名稱：

人MAML3重組蛋白
貨號：

CSB-YP839351HU
規格：
來源：

Yeast
其他：

中文名稱：

人MAML3重組蛋白
貨號：

CSB-EP839351HU
規格：
來源：

E.coli
其他：

中文名稱：

人MAML3重組蛋白
貨號：

CSB-EP839351HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人MAML3重組蛋白
貨號：

CSB-BP839351HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人MAML3重組蛋白
貨號：

CSB-MP839351HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

MAML3
Uniprot No.：

Q96JK9
別名：

AV234550; BC049812; CAG repeat containing (glia-derived nexin I alpha); CAG repeat domain; CAGH3; ERDA3; Expanded repeat domain, CAG/CTG 3; GDN; KIAA1816; MAM 2; Mam 3; MAM2; MAML3; MAML3_HUMAN; mastermind like 3 (Drosophila); Mastermind like 3; Mastermind like transcriptional coactivator 3; Mastermind-like protein 3; MGC59565; mKIAA1816; Polyglutamine rich; TNRC3; Trinucleotide repeat containing 3
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
基因功能參考文獻：
1. RBPJ and MAML3 could be new therapeutic targets for SCLC. PMID: 30061220
2. PTTG1IP and MAML3 are associated with BHR severity in adult asthma. The relevance of these genes is supported by the eQTL analyses and co-expression of PTTG1lP with vimentin and E-cadherin1, and MAML3 with MAML2. PMID: 27709636
3. These findings indicate that the miR-2392-MAML3/WHSC1-Slug/Twist1 regulatory axis plays a critical role in GC metastasis. PMID: 28512191
4. Results show that overexpression of MAML3 confers resistance to retinoic acid in multiple neuroblastoma cell lines. PMID: 26785999
5. These results suggest that PSK suppresses Hedgehog signaling through down-regulation of MAML3 and RBPJ transcription under hypoxia, inhibiting the induction of a malignant phenotype in pancreatic cancer. Our results may lead to development of new treatments for refractory pancreatic cancer using PSK as a Hedgehog inhibitor PMID: 27466498
6. Suggest that hypoxia promotes SMO transcription through upregulation of MAML3 and RBPJ to induce proliferation, invasiveness and tumorigenesis in pancreatic cancer. PMID: 26655998
7. Identification of new human proteins defines a family that consists of positive regulators for notch signaling PMID: 12386158
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亞細胞定位：

Nucleus speckle. Note=Nuclear, in a punctate manner.
蛋白家族：

Mastermind family
數據庫鏈接：

HGNC: 16272

OMIM: 608991

KEGG: hsa:55534

STRING: 9606.ENSP00000421180

UniGene: Hs.586165