Recombinant Human 2'-5'-oligoadenylate synthase 3 (OAS3), partial

中文名稱：

人OAS3重組蛋白
貨號：

CSB-YP897591HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人OAS3重組蛋白
貨號：

CSB-EP897591HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人OAS3重組蛋白
貨號：

CSB-EP897591HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人OAS3重組蛋白
貨號：

CSB-BP897591HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人OAS3重組蛋白
貨號：

CSB-MP897591HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

OAS3
Uniprot No.：

Q9Y6K5
別名：

(2-5'')oligo(A) synthase 3; 2 5' oligo(A) synthetase 3; 2 5'LIGO; 2 5A synthetase 3; 2''-5''-oligoadenylate synthase 3; 2-5A synthase 3; MGC133260 ; OAS3 2' 5' oligoadenylate synthetase 3, 100kDa ; OAS3; OAS3_HUMAN; p100; p100 OAS; p100OAS
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
基因功能參考文獻：
1. Mitochondrial C11orf83 is a potent antiviral protein independent of interferon production; and knockdown of either OAS3 or RNase L impaired the antiviral capability of C11orf83. PMID: 28418037
2. Protein-coding rare variations on the OAS3 gene are associated with the coexistence of HBsAg and anti-HBs in patients with chronic hepatitis B infection in Chinese Han population. PMID: 29582521
3. The study findings suggest that the OAS3 rs1859330 G/A genetic polymorphism is associated with the severity of enterovirus 71 (EV71) infection, and that the A allele is a risk factor for the development of severe EV71 infection. PMID: 28444539
4. Here we report, to our knowledge, the first analysis of nuclear signal import in the pseudo enzymatic domain DI of human OAS3 PMID: 27379722
5. OAS3 displayed a higher affinity for dsRNA in intact cells than either OAS1 or OAS2, consistent with its dominant role in RNase L activation. PMID: 26858407
6. By means of an allelic association study of a cohort of 740 patients with dengue, the authors found a protective effect of OAS3_R381 against shock. PMID: 26063222
7. Common variation at 12q24.13 (OAS3 intron) influences chronic lymphocytic leukemia risk. PMID: 25363670
8. The combined high affinity for double-stranded RNA and the capability to produce 2'-5'-linked oligoadenylates of sufficient length to activate RNase L suggests that OAS3 is a potent activator of RNase L. PMID: 25275129
9. OAS are interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation [review] PMID: 17408844
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

2-5A synthase family
組織特異性：

Present at high level in placenta trophoblast.
數據庫鏈接：

HGNC: 8088

OMIM: 603351

KEGG: hsa:4940

STRING: 9606.ENSP00000228928

UniGene: Hs.528634