Recombinant Chicken Paxillin (PXN), partial

中文名稱：

雞PXN重組蛋白
貨號：

CSB-YP019112CH
規格：
來源：

Yeast
其他：

中文名稱：

雞PXN重組蛋白
貨號：

CSB-EP019112CH
規格：
來源：

E.coli
其他：

中文名稱：

雞PXN重組蛋白
貨號：

CSB-EP019112CH-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

雞PXN重組蛋白
貨號：

CSB-BP019112CH
規格：
來源：

Baculovirus
其他：

中文名稱：

雞PXN重組蛋白
貨號：

CSB-MP019112CH
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PXN
Uniprot No.：

P49024
別名：

PXNPaxillin
種屬：

Gallus gallus (Chicken)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of v-CRK.
基因功能參考文獻：
1. Data suggest that the first LD motif (LD1; leucine-rich motif) of paxillin binds to the CCHD (C-terminal region of Cas family homology domain) of p130Cas/Bcar1 (in a 1:1 stoichiometry with Kd approximately 4.2 uM); p130Cas/Bcar1 CCHD is stabilized by forming complex with paxillin LD1; these studies utilized chicken paxillin and mouse p130Cas/Bcar1. (p130Cas/Bcar1 = breast cancer anti-estrogen resistance protein 1) PMID: 28860193
2. Data indicate that chicken paxillin leucine-aspartate LD2 and LD4 motifs preferentially dock at the helix 2/3 binding site of human Proline-rich tyrosine kinase 2 (Pyk2)-focal adhesion kinase (FAK). PMID: 25174335
3. Phosphorylation of paxillin LD4 results in a reduction of binding affinity to FAK. PMID: 18092823
亞細胞定位：

Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex.
數據庫鏈接：

KEGG: gga:395832

STRING: 9031.ENSGALP00000011713

UniGene: Gga.4056