JUND Recombinant Monoclonal Antibody

說明書

中文名稱：

JUND Recombinant Monoclonal Antibody
貨號：

CSB-RA088540A0HU
規(guī)格：

￥1320
圖片：
Flow cytometric analysis of JUND expression in HepG2 cells using JUND antibody. Green, isotype control; red, JUND.

Immunocytochemical staining of HepG2 cells with JUND antibody. Nuclei were stained blue with DAPI; JUND was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.

Western blotting analysis using JUND antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with JUND antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P17535
基因名：

JUND
別名：

JUND; JunD Proto-Oncogene, AP-1 Transcription Factor Subunit; AP-1; Transcription Factor AP-1 Subunit JunD; Transcription Factor Jun-D; Transcription Factor JunD; Activator Protein 1; Jun D Proto-Oncogene; JunD-FL Isoform
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human JUND protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

20E2
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB, FC, ICC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
FC	1:200-1:2000
ICC	1:100-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Transcription factor binding AP-1 sites.
基因功能參考文獻：
1. Data indicate the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and suggest structural insight for therapeutic interventions targeting AP-1 proteins. PMID: 28981703
2. In T cells, after serum deprivation HBZ induces the expression of Delta JunD isoform. Unlike JunD, Delta JunD induces proliferation and transformation of cells. HBZ bypasses translational control of JunD uORF and favors the expression of Delta JunD. The truncated isoform Delta JunD has a central role in the oncogenic process leading to adult T-cell leukemia . PMID: 28260789
3. MiR-663a suppresses proliferation and invasion by targeting AP-1 component JunD in non-small cell lung cancer cells. PMID: 27184257
4. studies showed that down-regulation of JunD in response to TGF-beta treatment is mediated via the proteasomal degradation pathway. PMID: 27358408
5. recombinant SERPINE2 induced a clear inhibition of MMP-13 expression in IL-1alpha-stimulated chondrocytes. This inhibitory effect is likely regulated through a pathway involving ERK 1/2, NF-kappaB and AP-1 PMID: 26305372
6. miR-494 is a novel regulator of HNPC apoptosis induced by TNF-alpha PMID: 25906693
7. JunD activates miR-29b by enhancing its transcription and processing, which contribute to the inhibitory effect of JunD PMID: 25788572
8. Cells in contact with basement membrane undergo transient oscillations between two molecular states defined by their TGFBR3- JUND expression. PMID: 24658685
9. BAG3 stabilized JunD mRNA. PMID: 24140207
10. This genotype-phenotype correlation study confirmed the lack of direct genotype-phenotype correlations. However, patients with mutations affecting the JunD interacting domain had a higher risk of death secondary to a MEN1 tumor PMID: 23376981
11. HTLV-1 bZIP factor(hbz) requires cellular JunD to upregulate HTLV-1 antisense transcription from the 3' long terminal repeat. PMID: 22696638
12. results demonstrate the presence of a common oncogenic cascade initiated by FRA2/JUND in CCR4-expressing mature T-cell malignancies such as ATLL and CTCLs PMID: 22493372
13. crystal structures of human menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1-LEDGF heterodimer PMID: 22327296
14. Apoptosis induction by dominant negative JunD is due to induction of growth arrest and DNA damage inducible proteins (GADD) 45 alpha and 45 gamma proteins. PMID: 21734453
15. JunD mediates, whereas c-Jun modulates, prostaglandin E2 activation of aromatase promoters PMID: 21393445
16. data indicate that JunD is an inhibitor of RHOH gene expression. PMID: 21473742
17. These results suggest that the induction of MMP-7 by Tax is regulated by JunD and that MMP-7 could facilitate visceral invasion in adult T-cell leukemia . PMID: 21315773
18. An alternative model of H ferritin promoter transactivation by c-Jun PMID: 11903046
19. JunD activated by LHRH acts as a modulator of cell proliferation and cooperates with the anti-apoptotic and anti-mitogenic functions of LHRH. PMID: 12054733
20. junD activation by ultraviolet rays plays a role in apoptosis in myeloblastic leukemia ML-1 cells PMID: 12082101
21. Translation initiation from alternative AUG and non-AUG sites in human, mouse and rat. PMID: 12105216
22. Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. PMID: 12727841
23. Menin is important for recruiting an mSin3A-histone deacetylase complex to repress JunD transcriptional activity. PMID: 14559791
24. Data show that human T-cell leukemia virus type I (HTLV-I) bZIP factor can activate JunD-dependent transcription and that its amino-terminus is required. PMID: 15044019
25. menin suppresses osteoblast maturation, in part, by inhibiting the differentiation actions of JunD PMID: 15563473
26. JunD is another ARE regulatory protein for transcriptional activation of the human ferritin H gene and probably other antioxidant genes containing the conserved ARE sequences by which JunD may confer cytoprotection during oxidative stress PMID: 16007120
27. JunD limits cardiomyocyte hypertrophy and protects the pressure-overloaded heart from cardiac apoptosis PMID: 16129800
28. Menin's dynamic regulation of histone modifiers with JunD is responsible for PKC theta-synergistic effect on Nur77 expression in T cell PMID: 16264271
29. Our data suggest that JUND and CLDN4 are critical mediators of the antiproliferative and antiviral effects of type I IFNs and further confirm the functional importance of the DNA-binding domain of Stat2. PMID: 17651017
30. aberrantly expressed Fra-2 in association with JunD may play a major role in CCR4 expression and oncogenesis in adult t-cell leukemia. PMID: 18071306
31. evidence is provided that HBZ/JunD heterodimers interact with Sp1 transcription factors and that activation of hTERT transcription by these heterodimers is mediated through binding sites for Sp1 present in the hTERT promoter. PMID: 18078517
32. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. PMID: 18321953
33. JunD overexpression increases production of reactive oxygen species in LNCaP cells in a low androgen environment. PMID: 18386285
34. JunD is a major determinant of macrophage activity and is associated with glomerulonephritis susceptibility. PMID: 18443593
35. JunD activation reduces the proliferation of cancer cells. PMID: 18454173
36. JunD is a biological suppressor of ZO-1 expression in intestinal epithelial cells and plays a critical role in maintaining epithelial barrier function PMID: 18562690
37. Activated c-Jun is dimerized with JunD in response to adrenomedullin. PMID: 19166930
38. Data suggest that TGF-beta1 up-regulates angiotensinogen transcription through a mechanism that requires both JunD and HIF-1alpha binding to the AGT core promoter, and that a molecular mechanism links hypoxia signaling and fibrogenic stimuli in the lung. PMID: 19211927
39. Decreased Jun-D and myogenin expression in muscle wasting of human cachexia. PMID: 19470832
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亞細胞定位：

Nucleus.
蛋白家族：

BZIP family, Jun subfamily
數(shù)據(jù)庫鏈接：

HGNC: 6206

OMIM: 165162

KEGG: hsa:3727

STRING: 9606.ENSP00000252818

UniGene: Hs.2780

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