GPRK6 Recombinant Monoclonal Antibody

說明書

中文名稱：

GPRK6 Recombinant Monoclonal Antibody
貨號：

CSB-RA940204A0HU
規格：

￥1320
圖片：
Flow cytometric analysis of G protein-coupled receptor kinase 6 expression in HepG2 cells using G protein-coupled receptor kinase 6 antibody. Green, isotype control; red, G protein-coupled receptor kinase 6.

Western blotting analysis using G protein-coupled receptor kinase 6 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with G protein-coupled receptor kinase 6 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
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靶點詳情

產品詳情

Uniprot No.：

P43250
基因名：

GPRK6
別名：

GRK6; G Protein-Coupled Receptor Kinase 6; GPRK6; EC 2.7.11.16; G Protein-Coupled Receptor Kinase GRK6; EC 2.7.11
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human GPRK6 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

16F11
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, FC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
FC	1:200-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
基因功能參考文獻：
1. GRK6 overexpression can significantly enhance tumor proliferation and invasion, which was consistent with clinical findings. PMID: 29805156
2. Genetic variation in OXTR and GRK6 is associated with the amount of oxytocin required as well as the duration of labor and risk for cesarean delivery among women undergoing induction of labor near term. PMID: 28526450
3. This work demonstrates the importance of GRK6 in regulation of hematopoietic stem cell self-renewal and reveals its potential role in participation of stress response. PMID: 27882944
4. Decreased expression of GRK6 may serve as an independent predictor of overall survival in lung adenocarcinoma. PMID: 27601164
5. The expression of GRK6 mRNA and protein was significantly lower in hypopharyngeal squamous cell carcinoma than in corresponding adjacent non-tumor tissues. This was associated with aberrant methylation of the gene. PMID: 26718636
6. Our results imply that GRK6 may not play a role in the pathophysiology of schizophrenia among Han Chinese PMID: 24302161
7. these results indicate that GRK6 complexes with AGS3-Galphai2 to regulate CXCR2-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane. PMID: 24510965
8. GRK6 plays a predominant role in phosphorylation of FFA receptor (FFA)4. PMID: 24412271
9. results suggested that GRK6 overexpression plays an important role in hepatocellular carcinoma PMID: 23375037
10. Downregulation of GRK6 expression enhances CXCR4 signaling and promoted medulloblastoma cell migration. PMID: 23497290
11. A reduced cortical concentration of GRK6 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia. PMID: 21784156
12. inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma. PMID: 19996089
13. A number of double mutations of GRK6 kinase within helices 3, 9, and 10 reduced phosphorylation of the beta2 adrenergic receptor and rhodopsin compared to wild-type GRK6 kinase. PMID: 20038610
14. Recruitment of beta-Arrestin 2, but not beta-Arrestin 1, to the active WHIM-mutant receptor is delayed compared to the WT CXCR4 receptor and Grk6 fails to associate with the WHIM-mutant receptor. PMID: 19956569
15. potential role of endogenous GRK6 in the regulation of M(3) mACh receptor PMID: 11856737
16. GRK6 is potential marker for organ injury and survival after cardiopulmonary bypass PMID: 12552191
17. the CRH-R1alpha carboxyl tail is important for regulation of receptor activity by G protein-coupled receptor kinase PMID: 15498832
18. the crystalline GRK6 RGS homology domain forms an extensive dimer interface using conserved hydrophobic residues distinct from those in GRK2 that bind Galpha(q) PMID: 16613860
19. These results suggest that the C-terminus of GRK6A contains a novel electrostatic palmitoyl switch in which acidic residues weaken the membrane-binding strength of the amphipathic helix.[GRK6A] PMID: 17538017
20. oxytocin receptor responsiveness is regulated by G protein-coupled receptor kinase 6 in human myometrial smooth muscle PMID: 19423652
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亞細胞定位：

Membrane; Lipid-anchor.
蛋白家族：

Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 4545

OMIM: 600869

KEGG: hsa:2870

STRING: 9606.ENSP00000433511

UniGene: Hs.235116

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