CYFIP1 Recombinant Monoclonal Antibody
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中文名稱：CYFIP1 Recombinant Monoclonal Antibody
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貨號：CSB-RA941550A0HU
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規格：￥1320
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圖片：
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Flow cytometric analysis of cytoplasmic FMR1 interacting protein 1 expression in HepG2 cells using cytoplasmic FMR1 interacting protein 1 antibody. Green, isotype control; red, cytoplasmic FMR1 interacting protein 1. -
Western blotting analysis using cytoplasmic FMR1 interacting protein 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with cytoplasmic FMR1 interacting protein 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：CYFIP1; Cytoplasmic FMR1 Interacting Protein 1; P140SRA-1; KIAA; Cytoplasmic FMRP Interacting Protein 1; Cytoplasmic FMR1-Interacting Protein 1; Specifically Rac1-Associated Protein 1; Selective Hybridizing Clone; P140sra-1; SRA-1; Sra-1; SRA1
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反應種屬：Human, Mouse, Rat
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免疫原：Recombinant Human CYFIP1 protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：14F6
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, FC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 FC 1:200-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. May act as an invasion suppressor in cancers.
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基因功能參考文獻：
- CYFIP1 gene expression was upregulated in the blood of epileptic patients. PMID: 29992499
- The studies suggest that MNK-eiF4E axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1. (Review) PMID: 27527252
- rs4778298, a common variant at CYFIP1 is associated with inter-individual variation in surface area across the left supramarginal gyrus. PMID: 27351196
- Both mRNA and protein expression levels of Cyfip1 were significantly lower in ALL patients. PMID: 26779626
- Reduced CYFIP1 in human neural progenitors results in dysregulation of schizophrenia and epilepsy gene networks. PMID: 26824476
- Hippocampal synapses with reduced Cyfip1 are larger and release neurotransmitter more rapidly. PMID: 26843638
- Data confirm that CYFIP1 is upregulated in transformed lymphoblastoid cell lines and demonstrate its upregulation in the post-mortem brain from 15q11-13 duplication patients for the first time PMID: 25311365
- This study confirmed that CYFIP2 were altered in postsynaptic density in patient with schizophrenia. PMID: 25048004
- haploinsufficiency causes cell polarity defects via WAVE complex destabilization; genetic polymorphism is associated with schizophrenia PMID: 24996170
- An imbalance of specific isoforms of CYFIP1, an FMRP interaction partner, and CAMK4, a transcriptional regulator of the FMRP gene, modulates risk for autism spectrum disorders. PMID: 24442360
- Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the trans-golgi network. PMID: 20228810
- located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes PMID: 14508708
- CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation PMID: 16260607
- quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5 in Prader-Willi syndrome and correlated levels with psychological and behavior scales PMID: 16982806
- Study found that Cyfip1, a subunit of the WAVE complex, which regulates cytoskeletal dynamics, is commonly deleted in human epithelial cancers. PMID: 19524508
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亞細胞定位：Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, synapse, synaptosome.
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蛋白家族：CYFIP family
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數據庫鏈接：
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