STS Antibody

說明書

中文名稱：

STS兔多克隆抗體
貨號：

CSB-PA022883GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P08842
基因名：

STS
別名：

STS; ARSC1; Steryl-sulfatase; Arylsulfatase C; ASC; Estrone sulfatase; Steroid sulfatase; Steryl-sulfate sulfohydrolase
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human STS
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
基因功能參考文獻：
1. Polymorphisms of STS gene is associated with attention-deficit/hyperactivity disorder. PMID: 28367959
2. STS is increased in preeclamptic placentas and maternal whole blood. Our data suggests that STS may affect sFlt1 secretion by regulating sFlt1-i13 transcription, and not via alterations in syncytialisation. PMID: 27871476
3. This study reveals that STS is a key player of steroid biosynthesis regulating the availability of circulating cholesterol. PMID: 27531568
4. In contrast to the situation in boys with ADHD, in healthy men, the G-allele at rs17268988 of STS is associated with enhanced cognition. PMID: 28293481
5. miR-661 overexpression sensitized tumors to TRAIL or STS induced apoptosis in a xenograft mouse model, and these effects were attenuated by co-expression of CYC1. PMID: 28391262
6. Collectively, STS point mutations demonstrate restricted localization, causing efficient impairment of the corresponding enzyme activity, and are more unlikely to be responsible for the phenotypic heterogeneity in XLRI subjects PMID: 26387488
7. STS expression was not significantly associated with DFS and OS, despite positive STS expression in 27% of endometrial cancer patients. Therefore, the role of STS as a prognostic factor in patients with endometrial cancer remains unclear and requires further research. PMID: 26996578
8. The induced STS facilitates the conversion of inactive estrogen sulfates to active estrogens, which in return attenuates the NF-kappaB-mediated inflammation. PMID: 26220752
9. The antagonistic actions of glucocorticoids and NFkB on STS expression are similar to the regulation of inflammatory response proteins PMID: 26631368
10. Letter/Case Report: novel nonsense mutation in the STS gene in X-linked ichthyosis. PMID: 26421812
11. Data show that both estrogen sulfatase (STS) and estrogen sulfotransferase (EST) were highly expressed in the human umbilical vein endothelial cells (HUVECs). PMID: 26458420
12. Effects of steroid hormone on estrogen sulfotransferase and on steroid sulfatase expression in endometriosis tissue and stromal cells PMID: 26723541
13. represents one of the major pathways in regenerating biologically active steroids in both steroidogenic and nonsteroidogenic tissues [review] PMID: 26213785
14. Our analyses show that the two phenotypes in our patient are due to independent genetic defects: a genomic rearrangement involving the Kallmann syndrome 1 gene and a point mutation of the steryl-sulfatase gene. PMID: 25726327
15. In both arm and subumbilical skin biopsy of patients with idiopathic hirsutism, there was an up-regulation of STS mRNA expression. PMID: 26194504
16. Genetic variation in ARSC may be associated with change in mammographic density after women stop using estrogen-progestin therapy. PMID: 25499601
17. STS is present in human pre-osteoblastic bone cells and that it can influence bone cell growth PMID: 25042472
18. complete deletion in Pakistani families with x-linked ichthyosis PMID: 24480088
19. results suggest that steroid sulfatase expression can be decreased in the process of large intestinal carcinogenesis PMID: 23916543
20. Data suggest that expression of STS and 17beta-hydroxysteroid dehydrogenase isoenzymes is up-regulated in subcutaneous abdominal fat of morbidly obese women as compared with morbidly obese men. PMID: 24081738
21. Microdeletion within Xp22.3 containing STS with aCGH in an individual with suspected pre-Descemet corneal dystrophy and X-linked ichthyosis demonstrates the clinical utility of copy number variation analysis. PMID: 23807007
22. IGF-II induces steroid sulfatase expression via a PI3-kinase/Akt-NF-kappaB signaling pathway in PC-3 cells and may induce estrogen production and estrogen-mediated carcinogenesis. PMID: 24055520
23. Genetic variants in SULT2A1, PAPSS2, and STS do not predispose to polycystic ovary syndrome. PMID: 23861462
24. no difference in placental activity found between women with polycystic ovarian syndrome and controls PMID: 23122578
25. Genetic variants affecting steroid sulfatase expression and/or activity could influence the function of brain regions perturbed in attention deficit hyperactivity disorder (ADHD). PMID: 21255266
26. Filaggrin defects can synergize with steroid sulfatase deficiency to exacerbate the ichthyosis phenotype. PMID: 21945601
27. Recent results of STS and EST in several estrogen-dependent carcinomas, are summarised. PMID: 21073915
28. This timely review concentrates on recent advances in steroid sulfatase research. PMID: 21693170
29. Case Report: Report novel point mutation in the STS gene in a patient with X-linked recessive ichthyosis. PMID: 21530180
30. Genetic variation in the STS gene may be implicated in ADHD susceptibility and one polymorphism may be associated with lower STS mRNA expression as well as being more prevalent in female ADHD homozygotes. PMID: 20862695
31. Recessive X-linked ichthyosis is caused by a deficiency in steroid sulphatase (STS), whose gene has been located on the X chromosome. PMID: 20236202
32. Six novel single nucleotide polymorphisms of the steroid sulfatase gene in a Japanese population. PMID: 20814163
33. A significant increment of STS followed exemestane neoadjuvant therapy of postmenopausal ER-positive breast carcinoma. This may represent the compensatory response of breast carcinoma tissues to estrogen depletion. PMID: 20151319
34. Both steroid sulfatase and filaggrin mutations are found in X-linked ichthyosis. PMID: 20149601
35. Analysis of deletions indicates complex origin, apart from homologous recombination, of deletion mutants. PMID: 11844872
36. in the human hair follicle, concentrates in the dermal papilla. PMID: 11886493
37. Regulation of estrogen activity in human endometrium: effect of IL-1beta on steroid sulfatase activity in human endometrial stromal cells. PMID: 11996939
38. data demonstrate that LNCaP prostate cancer cells contain a steryl sulfatase with properties similar to that found in human breast cancer cells PMID: 12231117
39. The structure of this enzyme, purified from the microsomal fraction of human placentas, determined by x-ray crystallography. PMID: 12657638
40. Levels of STS and estrogen sulfotransferase mRNA and activity may be significantly associated with degree of atherosclerotic changes in female aorta, which may be related to cytokines produced in situ, such as IL-1beta, in human atherosclerotic lesions. PMID: 14507642
41. estrogen-dependent cell growth of the estrogen sulfatase-transfected cell clones was found to be abolished, due to the enhanced sulfoconjugation of estrogen PMID: 14556660
42. Steroid sulfatase increases steroid acute regulatory protein expression level and stimulates steroid production. PMID: 14969586
43. SSase is concentrated in lamellar bodies (LB), and secreted into the SC interstices, along with other LB-derived lipid hydrolases. There, it degrades CSO4, generating some cholesterol for the barrier PMID: 15009711
44. Strong activity and mRNA expression of DHEAS desulfating STS was found, twice as high in cerebral neocortex than in subcortical white matter. Cerebral STS resembled the characteristics of the known placental enzyme PMID: 15056284
45. Dehydroepiandrosterone blood levels are influenced by a steroid sulfatase polymorphism following acute resistance exercise. PMID: 15152080
46. Gonadotropin-releasing hormone agonist (leuprolide)inhibits estrone sulfatase expression in cystic endometriosis in the ovary. PMID: 15302278
47. Increased steroid sulfatase expression is associated with estrogen-dependent endometrial carcinomas PMID: 15355916
48. Findings of steroid sulfatase localized in the cytoplasm of the cumulus cells and expression of STS mRNA suggest a local steroidal regulation mechanism in cumulus cells. PMID: 16084891
49. Studies on the localization of steroid sulfatase were performed. PMID: 16399357
50. Corticotrophin-releasing hormone (CRH) increased whereas alpha-helical CRH decreased the mRNA levels of STS, CYP19A1, and HSD17B1, the key enzymes for estrogen synthesis. PMID: 16467490
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相關疾病：

Ichthyosis, X-linked (IXL)
亞細胞定位：

Cytoplasmic vesicle, secretory vesicle, microneme membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

Sulfatase family
數據庫鏈接：

HGNC: 11425

OMIM: 300747

KEGG: hsa:412

STRING: 9606.ENSP00000217961

UniGene: Hs.522578

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