RFC3 Antibody

說明書

產品詳情

Uniprot No.：

P40938
基因名：

RFC3
別名：

A1 38 kDa subunit antibody; Activator 1 38 kDa subunit antibody; Activator 1 subunit 3 antibody; HGNC:9971 antibody; MGC5276 antibody; Replication factor C (activator 1) 3 antibody; Replication factor C (activator 1) 3, 38kDa antibody; Replication factor C 3 antibody; Replication factor C 38 kDa subunit antibody; Replication factor C subunit 3 antibody; RF-C 38 kDa subunit antibody; RFC 38 kD subunit antibody; RFC 38 kDa subunit antibody; RFC3 antibody; RFC3_HUMAN antibody; RFC38 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human RFC3.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.
基因功能參考文獻：
1. The expression level of RFC3 was markedly upregulated in the HCC tissues and cells. PMID: 26397132
2. The expression level of RFC3 was remarkably up-regulated in ovarian cancer OVCAR-3 cells. Down-regulation of RFC3 expression arrested the cell cycle of OVCAR-3 cell in the S-phase and induced apoptosis. PMID: 26464638
3. High RFC3 expression is associated with neoplastic myelopoiesis. PMID: 25541153
4. our findings suggest that RFC3 protein is an important and independent biomarker with prognostic implications for patients with ovarian carcinoma. PMID: 25030735
5. 9-cis-RA-activated RXRalpha suppresses the growth of retinoid-sensitive breast cancer and embryonic cells through RFC3. PMID: 22949521
6. Data identified RFC3 as a candidate oncogene amplified in esophageal adenocarcinoma (EAC). PMID: 22328562
7. RFC3 mutation and loss of RFC3 expression occur in large fractions of gastric and colorectal cancers and suggest that these alterations may contribute to the cancer pathogenesis by deregulating DNA repair and replication. PMID: 20573375
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亞細胞定位：

Nucleus.
蛋白家族：

Activator 1 small subunits family
數據庫鏈接：

HGNC: 9971

OMIM: 600405

KEGG: hsa:5983

STRING: 9606.ENSP00000369411

UniGene: Hs.115474

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