PRDM2 Antibody
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中文名稱：PRDM2兔多克隆抗體
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貨號：CSB-PA921106
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA921106(PRDM2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA921106(PRDM2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：PRDM2
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別名：GATA-3-binding protein G3B antibody; HUMHOXY1 antibody; KMT8 antibody; Lysine N-methyltransferase 8 antibody; MTB-ZF antibody; MTE-binding protein antibody; PR domain containing 2; with ZNF domain antibody; PR domain zinc finger protein 2 antibody; PR domain-containing protein 2 antibody; PRDM2 antibody; PRDM2_HUMAN antibody; Retinoblastoma protein binding zinc finger protein antibody; Retinoblastoma protein-interacting zinc finger protein antibody; Retinoblastoma protein-interacting zinc-finger protein antibody; RIZ antibody; RIZ1 antibody; RIZ2 antibody; Zinc finger DNA binding protein antibody; Zinc finger protein RIZ antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthetic peptide of Human PRDM2
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
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基因功能參考文獻：
- The authors have found that overexpression of RIZ1 in HEK293 cells reduced the expression of Akt3 protein. PMID: 29367689
- Promoter hypermethylation may play an important role in the epigenetic silencing of RIZ1 expression in human glioma tissues and glioblastoma cell lines. PMID: 27757741
- the Pro704 p-/- allele of RIZ is significantly more common in CML patients with Loss of hematological response than good responders (p = .001). We showed that LOH p-/- homozygosity of RIZ1 was common event in BC than proline p+/+ homozygosity and proline p+/+ homozygosity more common feature in CP phase CML. PMID: 27830966
- Promoter region methylation of RIZ1 may play an important role in the epigenetic silencing of RIZ1 expression in pituitary adenomas, which may translate into important diagnostic and therapeutic applications PMID: 28718376
- RIZ1 expression is negatively correlated with glioma differentiation and can serve as a predictor of glioma prognosis and thus could be a potential therapeutic target for patients with gliomas. PMID: 26690953
- Loss of RIZ1 expression due to methylation is associated with Renal Cell Carcinoma. PMID: 25987089
- PRDM2 downregulation may play a role in dopamine-agonist resistance and tumor recurrence in prolactinomas. PMID: 25884948
- Results suggest that high expression of SMYD3 is related to the occurrence of esophageal squamous cell carcinoma. Also, its suppression promoted the expression of RIZ1 suggesting a signal transduction pathway between SMYD3 and RIZ1. PMID: 24993551
- PRDM2, PRDM5, PRDM16 promoters are methylated and their expression is suppressed in lung cancer cells. PMID: 24966940
- The development and progression of esophageal squamous cell carcinoma are related to the inactivation of RIZ1. PMID: 24115813
- RIZ1 expression is significantly downregulated as the formation of meningiomas progressed, and suggest that RIZ1 may represent a promising candidate tumor suppressor gene that contributes to malignant meningiomas. PMID: 22614009
- Reduction of RIZ1 expression aggravates the progression of liver fluke-related cholangiocarcinoma PMID: 23098508
- Aberrant methylation and decreased expression of the RIZ1 gene are frequent in adult acute lymphoblastic leukemia of T-cell phenotype PMID: 22300346
- Data suggest that promoter methylation may play an important role in the epigenetic silencing of RIZ1 gene expression in human esophageal squamous cell carcinoma. PMID: 22363126
- Acting as a negative regulator of RIZ1 function, PRFM2 mediates effect of cell proliferation by estrogen via regulation of cell survival and differentiating gene expression. PMID: 21503890
- RIZ1 may be a potential tumor suppressor in human esophageal squamous cell cancer. PMID: 22372344
- RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity. PMID: 21369371
- Results suggest that the RIZ1 gene is inactivated in MDS and AML in part by methylation, whereas another mechanism should be involved in others. PMID: 20828818
- promoter methylation and H3K9 modifications work together to silence the RIZ1 gene in hepatocellular carcinoma (HCC). PMID: 20675009
- RIZ1 promoter methylation is not a common event in neuroblastoma. PMID: 20878080
- RIZ1 negatively regulated the cell proliferation of monocytic leukemia cells via activation of p53. PMID: 20594067
- Loss of RIZ1 expression will lead to an increase in myeloid blast cell population resulting in CML progression. PMID: 19602237
- Reduced expression of RIZ1 may play an important role in the pathogenesis and/or development of cervical cancer, and is considered to be caused in part by aberrant DNA methylation PMID: 20159667
- loss of RIZ1 mRNA in human cancers is associated with DNA methylation of its promoter CpG island. PMID: 11719434
- These findings suggest that RIZ may be a possible target of structural alteration leading to leukemia. PMID: 12002276
- Frameshift mutations of RIZ, but no point mutations, were found in RIZ1 exons in malignant melanomas with deletions in 1p36. RIZ has potential role in the multi-step tumor forming process of malignant melanoma of the skin. PMID: 12082534
- RIZ1 in gastric neoplasms undergoes biallelic inactivation. PMID: 14534544
- Tumor suppressor RIZ1 (PRDM2) methylates histone H3 on lysine 9, and this activity is reduced by mutations in the PR domain found in human cancers. PMID: 14633678
- Frameshift mutations of RIZ may play an important role in gastric cancers with microsatellite instability. PMID: 15309726
- the presented results indicated that the Zn-finger domain could be endowed with the putative oncogenic activity of RIZ2 gene product. PMID: 15488642
- RIZ1 may be a new candidate gene for involvement in the variation seen in bone mineral density. PMID: 15579774
- recurrent inactivation of the tumour suppressor RIZ1 suggests that this event may be a significant contributing factor to tumour development in pheochromocytomas and abdominal paragangliomas PMID: 15809732
- Forced RIZ1 expression in CML-BC cell lines decreases IGF-1 receptor activation and activation of downstream signaling components extracellular signal-regulated kinase 1/2 and AKT PMID: 16953217
- The current study suggested an important role for RIZ1 expression in thyroid tumorigenesis. PMID: 17103461
- A563G variant not found in diffuse large B-cell lymphomas. PMID: 17205536
- the ERalpha cofactor RIZ gene has a prominent effect on bone marrow density(BMD), and the P704 genotype modulates the impact of estradiol on BMD PMID: 17356055
- RIZ polymorphisms may be important predictive markers for lung cancer susceptibility. PMID: 17693662
- Reduced expression of RIZ1 may play an important role in the pathogenesis and/or development of epithelial ovarian carcinoma, and is considered to be caused in part by aberrant DNA methylation. PMID: 17922684
- The proliferation, migration induction and apoptosis inhibition activities of SMYD3 in hepatocellular carcinoma may be mediated through RIZ1 CpG promoter hypermethylation. PMID: 17963297
- observed no association of the RIZ1 Pro704 insertion-deletion polymorphism with BMD or fracture risk PMID: 18037365
- Results suggest that the inactivation of the RIZ1 by DNA methylation at its promoter region is involved in the tumorigenesis of hepatocellular carcinoma, particularly in the early stage of disease. PMID: 18712668
- methyl-balanced diet conferred additional survival benefits compared to a tumor-inducing methyl-imbalanced diet only in mice with wild type RIZ1 but not in mice deficient in RIZ1 PMID: 18852888
- RIZ1 is expressed in normal prostate epithelial cells and down-regulated in cancer cells, with a switch of its localization from the nucleus to the cytoplasm upon cancer grade progression. RIZ1 levels were modulated by DHT or E2 treatment in vitro. PMID: 19746436
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亞細胞定位：Nucleus.
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蛋白家族：Class V-like SAM-binding methyltransferase superfamily
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組織特異性：Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.
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