CLIP2 Antibody

中文名稱：

CLIP2兔多克隆抗體
貨號：

CSB-PA871393LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat brain tissue, Mouse brain tissue
All lanes: CLIP2 antibody at 3.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 116, 112 kDa
Observed band size: 116 kDa

Immunofluorescence staining of A549 cells with CSB-PA871393LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CLIP2 Polyclonal antibody
Uniprot No.：

Q9UDT6
基因名：

CLIP2
別名：

CAP GLY domain containing linker protein 2 antibody; CAP-Gly domain-containing linker protein 2 antibody; CLIP 115 antibody; CLIP antibody; CLIP-115 antibody; Clip2 antibody; CLIP2_HUMAN antibody; cytoplasmic linker 2 antibody; Cytoplasmic linker protein 115 antibody; Cytoplasmic linker protein 2 antibody; KIAA0291 antibody; MGC11333 antibody; restin antibody; Similar to RESTIN (CYTOPLASMIC LINKER PROTEIN 170 ALPHA 2) antibody; WBSCR3 antibody; WBSCR4 antibody; Williams Beuren syndrome chromosome region 3 antibody; Williams Beuren syndrome chromosome region 4 antibody; Williams-Beuren syndrome chromosomal region 3 protein antibody; Williams-Beuren syndrome chromosomal region 4 protein antibody; WSCR3 antibody; WSCR4 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human CAP-Gly domain-containing linker protein 2 protein (101-217AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CLIP2 Antibody (CSB-PA871393LA01HU)，的標記方式是Non-conjugated。對于CLIP2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA871393LB01HU	CLIP2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA871393LC01HU	CLIP2 Antibody, FITC conjugated
Biotin	CSB-PA871393LD01HU	CLIP2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations.
基因功能參考文獻：
1. Cross checking with epidemiological estimates and model validation suggests that CLIP2 is a marker of high precision. CLIP2 leaves an imprint in the epidemiological incidence data which is typical for a driver gene. PMID: 27729373
2. CLIP2 protein expression is elevated in papillary thyroid carcinomas from patients exposed to radioiodine fallout compared with a nonexposed control group. PMID: 25284583
3. A clear radiation dose-response relationship for the CLIP2 marker expression in post-Chernobyl papillary thyroid carcinomas PMID: 25957251
4. CLIP2 haploinsufficiency by itself does not lead to the physical or cognitive characteristics of the Williams-Beuren syndrome; GTF2IRD1 and GTF2I are the main genes causing the cognitive defects PMID: 22608712
5. Data show that gene CLIP2 was specifically overexpressed in the exposed cases. PMID: 21606360
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相關疾病：

CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region (PubMed:9799601). WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. However, it has been demonstrated that haploinsufficiency of this gene alone is not sufficient to cause any of the cognitive or facial features of WBS (PubMed:22608712).
亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton.
數據庫鏈接：

HGNC: 2586

OMIM: 603432

KEGG: hsa:7461

STRING: 9606.ENSP00000223398

UniGene: Hs.647018

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