CLEC10A Antibody, HRP conjugated
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中文名稱：CLEC10A兔多克隆抗體, HRP偶聯
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貨號：CSB-PA811601LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CLEC10A Polyclonal antibody
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Uniprot No.：
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基因名：CLEC10A
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別名：C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 13 (macrophage derived) antibody; C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 14 (macrophage derived) antibody; C type lectin domain family 10; member A antibody; C type lectin superfamily member 14 antibody; C-type lectin domain family 10 member A antibody; C-type lectin superfamily member 14 antibody; CD301 antibody; CD301 antigen antibody; CD301A antibody; CLC10_HUMAN antibody; CLEC10A antibody; CLECSF13 antibody; CLECSF14 antibody; HML antibody; HML2 antibody; Lectin antibody; Macrophage C type lectin antibody; MACROPHAGE GALACTOSE-TYPE C-TYPE antibody; Macrophage lectin 2 (calcium dependent) antibody; Macrophage lectin 2 antibody; MGL antibody; Mgl1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human C-type lectin domain family 10 member A protein (66-316AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
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基因功能參考文獻：
- this paper shows that key gene of intermediate proinflammatory monocytes, such as CLEC10A, is expressed three- to fourfold more in juvenile idiopathic arthritis-enthesitis-related arthritis PMID: 27706807
- BRAF(V600E) mutation induces MGL ligand expression, thereby providing a direct link between oncogenic transformation and aberrant expression of immunosuppressive glycans in colorectal neoplasms. PMID: 26172302
- These results indicate a role of MGL as an immunomodulator within the tumour microenvironment interfering with Treg functions, suggesting its possible use in the design of anticancer vaccines. PMID: 26147970
- expression of GalNAc moieties mirrors the T cell activation status, and thus only highly stimulated T cells are prone to the suppressive action of MGL. PMID: 23918927
- MGL triggering synergized with TLR2-induced pathways, leading to elevated IL-10 mRNA levels & enhanced TNF-alpha mRNA stability. It promoted phosphorylation of the ERK & CREB, fine-tuning the DC maturation phenotype. PMID: 23744646
- Described is the use of recombinant CLEC10A (CD301), a human glycoreceptor of the C-type lectin family, for the detection of ligands in sections from formalin-fixed, paraffin-embedded normal and cancerous mammary tissues. PMID: 23275449
- MGL engagement improved DC performance as antigen-presenting cells, promoting the upregulation of maturation markers, a decrease in phagocytosis, an enhancement of motility, and most importantly an increase in antigen-specific CD8(+) T-cell activation. PMID: 22531918
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亞細胞定位：Membrane; Single-pass type II membrane protein.
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